Background Acute blood purification (ABP) therapy is used regularly in the clinical setting and reportedly alleviates organ failure associated with severe systemic inflammatory responses, leading to reduced mortality. The present study aimed to determine whether there is a difference in efficacy between polysulfone (PS) membranes, which are currently used regularly in the clinical setting, and ...

The medaka fish (Oryzias latipes) is an emerging model organism for which a variety of unique developmental mutants have now been generated. Our recent mutagenesis screening of the medaka identified headfish (hdf), a null mutant for fgf receptor 1 (fgfr1), which fails to develop structures in the trunk and tail. Despite its crucial role in early development, the functions of Fgfr1-mediated sign...

It is well-established that some product(s) or metabolite(s) of mevalonate is (are) critical for growth of mammalian cells. In the search for this (these) compound(s) it seems meaningful to distinguish between compounds needed for cell cycle progression in proliferating cells and compounds needed for growth activation of arrested cells. By using time-lapse video recording we have studied the po...

Systemic sclerosis (SSc) is a chronic autoimmune disease, featuring fibrosis in multiple organs. The serum from SSc patients contain inflammatory mediators, contributing to SSc pathogenesis and could be used to develop cell culture models. Here, we compared the fibrotic effects of serum samples from SSc patients with TGFβ1 on human dermal fibroblasts (HDFs). HDF cells were cultured in four diff...

Background: The skin serves as the first line of defense for human body. Direct sunlight contains damaging radiations that can speed up ageing process skin, resulting in wrinkles, leathery dark patches, and solar elastosis. Objectives: To evaluate effect multiple irradiation related factors at protein level dermal fibroblast (HDF). overall individual irradiations such Infrared A (IRA), blue lig...

Online hemodiafiltration (OL-HDF) as a renal replacement therapy is gaining momentum due to the perceived added benefit from enhanced clearance of potential‐ ly harmful middle molecules. Favorable effect of OL-HDF on all-cause mortality and cardiovascular mortality and morbidity has been suggested by some clinical trials. Health-related quality of life (HRQOL) is an important component of hemod...

The quality, depth, and multi–color nature of the Hubble Deep Field images makes them an excellent resource for studying galaxies at z > 2 using selection techniques based on the presence of the 912Å Lyman break. I present a descriptive review of this method and of the properties of the objects which it identifies, and summarize spectroscopic progress on galaxies with 2 < z < 4 in the HDF. Usin...

We present deep imaging at 6.7 and 15 /lm from the CAM instrument on the Infrared Space Observatory (ISO), centred on the Hubble Deep Field (HDF). These are the deepest integrations published to date at these wavelengths in any region of sky. We discuss the observational strategy and the data reduction. The observed source density appears to approach the CAM confusion limit at 15 /lm, and fluct...

Cosmologically distant galaxies ought to act as multiply imaging gravitational lenses for a fraction ∼ 0.002−0.005 of background sources.[1, 2, 3] This prediction is being borne out by surveys of flat spectrum radio sources[4, 5] and optical surveys.[6, 7, 8] The incidence and character of strong gravitational lenses provide an important constraint on the source redshift distribution and world ...

Two new peptides derived from seaweed pipefish Syngnathus schlegeli, SPP-1(QLGNLGV) and SPP-2 (SVMPVVA) were assessed for their ability to prevent hydrogen peroxide induced oxidative stress in human dermal fibroblasts (HDFs). Both peptides showed a significant hydroxyl radical scavenging activity when tested by ESR technique. And also the peptides effectively suppressed the hydrogen peroxide in...