A simple, selective, sensitive and precise, simultaneous high performance liquid chromatographic analysis of syrup containing Chlorphineramine Maleate, Dextromethorphan HBr and Phenylephrin HCl was described. Good chromatographic separation was achieved using a Zorbax C18 (4.6 cm x 250 mm, 5 μm) and a mobile phase consisting of acetonitrile-phosphate buffer pH 3.5 (15:85, v/v) at a flow rate 0....

Six well known drugs, captopril, metformin-HCl, metroniazole, nortriptyline-HCl, fluoxetine-HCl and betahistin-HCl, were grafted to poly(styrene-alt-maleic anhydride) (PSMA). Grafting was attained by combining of anhydride groups in the PSMA with therapeutic agents containing NH, OH or SH groups. The covalently grafted drugs were identified by infrared, (1)H NMR and UV-Vis spectroscopy. The dru...

Hairy cell leukemia (HCL) is an indolent low-grade B-cell lymphoproliferative disorder that is reasonably sensitive to standard first-line purine analog therapy. However, in many cases, repeat relapses occur, requiring multiple courses of purine analog therapy, promoting eventual drug resistance. This, coupled with the concerning side effects of repeated purine analog exposure, has prompted the...

Body weight, uteri, serum cholesterol and bones were shown previously in vivo to be sensitive to circulating levels of estrogen, as well as to synthetic, nonsteroidal ligands termed selective estrogen receptor modulators (SERM). In this study, we examined the in vivo effects of a new potent SERM on these tissues in 6-month-old, ovariectomized rats that were orally dosed with 0.0001-10 mg/kg/day...

This paper presents the effect of Hydrochloric acid (HCl) on Blended Cement (Fly ash based(BC)) and Silica Fume Blended Cement(SFBC) and their concretes. The BC and SFBC and their concretes BCC and SFBCC produced with HCl dosage of 100, 150, 300, 500 and 900 mg/l added in deionised water. In addition to this control specimens were prepared with deionised water (without HCl) for comparison. The ...

Hairy cell leukemia variant (HCL-V) is a poorly described, rare B-cell lymphoproliferative disorder typically positive for CD103 and CD11c, while lacking CD25. Splenic marginal zone lymphomas (SMZL) also have this unusual phenotype in 15% to 25% of cases, have other overlapping clinical or morphologic features, and are more common than HCL-V. The purpose of our study was to better characterize ...

Reactions of atomic oxygen with complexes containing HCl are investigated and the OH product state distributions are compared to those observed for the corresponding reactions of HCl monomers. In previous studies of reactions of O(P) with HCl and hydrocarbon complexes, rotationally colder OH product state distributions were observed, when compared to the corresponding reactions of monomers. In ...

Polyclonal B lymphocytosis was found in four patients having clinical and hematologic features resembling those of hairy cell leukemia (HCL). All four patients were women between 37 and 67 years of age. Three patients had splenomegaly. Lymphadenopthy was absent or slight. Persistent lymphocytosis was seen in all the patients, and anemia and/or thrombopenia was observed in three of the patients....

The state-to-state vibrational predissociation dynamics of the hydrogen-bonded HCl-H(2)O dimer were studied following excitation of the HCl stretch of the dimer. Velocity-map imaging and resonance-enhanced multiphoton ionization (REMPI) were used to determine pair-correlated product energy distributions. Following vibrational excitation of the HCl stretch of the dimer, HCl fragments were detect...

Two types of unilateral lung edema in sheep were characterized regarding their effects on pulmonary gas exchange, hemodynamics, and distribution of pulmonary perfusion. One edema type was induced with aerosolized HCl (0.15 M, pH 1.0) and the other with NaCl (0.15 M, pH 7.4). Both aerosols were nebulized continuously for 4 h into left lungs. In HCl-treated animals, pulmonary gas exchange deterio...