HBV is a member of Hepadnavirus genus. HBV is a DNA virus with a diameter of 42 nm consisting of an outer lipid envelope which contains proteins HBsAg, pre-S1 and pre-S2. HBsAg is a product of ‘s’ gen. The s geneinvolves ‘a’ epitope124. -147. codones and this region is the affecting region for anti-HBs antibody binding. Vaccine /Immunglobulin escape mutations occur at HBV DNA s gene’s ‘a determ...

The aim of the current study was to evaluate viral suppression following combined treatment with an S/pre-S1/pre-S2 vaccine and lamivudine in patients with chronic hepatitis B. We established a randomized, controlled clinical trial to compare the responses of three different treatment groups: those receiving vaccine monotherapy, lamivudine monotherapy, or combination treatment. Viral response w...

Background: Thalassemia patients are more susceptible to hepatitis than the normal population due to the frequent blood transfusions. Objective: To determine the immune response of children with major ß-thalassemia, by measuring anti-hepatitis B surface antibody (anti-HBs Ab) following the last HBV vaccine injection. Methods: This study was carried out on 215 thalassemic children who received t...

Multivalent combination vaccines have reduced the number of injections and therefore improved vaccine acceptance, timeliness of administration and global coverage. The hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus/Haemophilus influenzae type b (DTPa-HBV-IPV/Hib; Infanrix hexa™) vaccine, administered according to various schedules, is widely used for the pr...

in order to determine the efficacy of recombinant hepatitis b vaccine in iranian infants, we analyzed the efficacy of a recombinant hepatitis b vaccine in 115 infants aged 12-24 months born to hbsag negative mothers who received three doses of hbv antibody to hepatitis b surface antigen (anti-hbs) was checked after the third dose of the vaccine, 94.8% of the infants had developed protective ant...

Hepatitis B virus (HBV) continues to be a worldwide public health concern. There are more than 240 million people with chronic infection across the globe and 780 000 deaths each year as a result of acute or chronic HBV. Infants born to mothers with chronic HBV infection are at very high risk of acquiring the virus and progressing to chronic infection. In the 1970s–1980s, HBV vaccine and high-ti...

Approximately 5-10% of individuals, who are vaccinated with a hepatitis B (HB) vaccine designed based on the HBV genotype C, fail to acquire protective levels of antibodies. Here, host genetic factors behind low immune response to this HB vaccine were investigated by a genome wide association study (GWAS) and HLA association tests. A GWAS and HLA association tests were carried out using a total...

conclusions dental academics were unsure about the means of infection and prevention against hbv. many of them had not completed the immunization scheme and did not have the test of seroconversion. the serological analysis revealed unprotection, even after students completed the vaccination schedule. results of the 179 students surveyed, 58.1% knew about the degree of virulence of the hepatitis...

BACKGROUND Vaccinating infants against hepatitis B virus (HBV) is the most effective way of preventing the disease. However, since HBV exposure can increase during adolescence, it is essential that antibody persistence is maintained. We evaluated the antibody persistence and immune memory against hepatitis B, in 12-13 y olds who had received complete primary + booster vaccination with diphtheri...