نتایج جستجو برای: hbv escape mutations

تعداد نتایج: 214596  

Journal: :hepatitis monthly 0
yong huang the key laboratory of molecular biology of infectious diseases designated by the chinese ministry of education, chongqing medical university, chongqing, china; department of clinical laboratory, second affiliated hospital, chongqing medical university, chongqing, china haijun deng the key laboratory of molecular biology of infectious diseases designated by the chinese ministry of education, chongqing medical university, chongqing, china zhi peng department of infectious disease, second affiliated hospital, chongqing medical university, chongqing, china yao huang the key laboratory of molecular biology of infectious diseases designated by the chinese ministry of education, chongqing medical university, chongqing, china quanxin long the key laboratory of molecular biology of infectious diseases designated by the chinese ministry of education, chongqing medical university, chongqing, china; the key laboratory of molecular biology of infectious diseases designated by the chinese ministry of education, chongqing medical university, chongqing, china. fax: +86-2368486780, e-mail:; ailong huang, the key laboratory of molecular biology of infectious disease designated by the chinese ministry of eductation, chongqing medical university, chongqing, china. ailong huang the key laboratory of molecular biology of infectious diseases designated by the chinese ministry of education, chongqing medical university, chongqing, china; the key laboratory of molecular biology of infectious diseases designated by the chinese ministry of education, chongqing medical university, chongqing, china. fax: +86-2368486780, e-mail:; ailong huang, the key laboratory of molecular biology of infectious disease designated by the chinese ministry of eductation, chongqing medical university, chongqing, china.

conclusions the mutation ratio difference between genotypes b and c in children was higher than that of adults and several combined mutations were exclusively detected in children with chronic hbv genotype c infection associated with higher viral load. objectives the aim of this study was to assess the mutation profiles of bcp and precore regions in different hbv genotypes in chronically infect...

Journal: :International journal of clinical and experimental medicine 2015
Xiaohong He Fang Wang Bin Huang Peisong Chen Liangying Zhong

OBJECTIVE To investigate the relationships of resistance mutations of hepatitis B virus (HBV) with replication and genotypes of HBV and to understand the common resistance mutations and mutation pattern. METHODS The mutation patterns related to resistance to nucleoside drugs were analyzed, and the relationships of resistance mutations with HBV genotypes, Ct value, HBeAg, alanine aminotransfer...

Journal: :Journal of hepatology 2013
Dwayne M Baxa Ashish D Thekdi Alicia Golembieski Prashant V Krishnan Omar Sharif Anne Kizy Lynne Shetron-Rama John Jovanovich Brandi J Chappell Andrea Snow-Lampart Katyna Borroto-Esoda Stuart C Gordon

BACKGROUND & AIMS Reported HBV drug resistance mutations among previously untreated patients with chronic hepatitis B are variable. Whether resistant HBV strains are transmitted in the acute setting is uncertain. We sought to document the presence of antiviral resistance (AVR) mutations in patients with acute HBV (AHB) infection. METHODS AHB infection was defined by HBsAg/IgM anti-HBc positiv...

Journal: :Antiviral therapy 2015
Michele S Gomes-Gouvêa Ariana C Ferreira Rosangela Teixeira José R Andrade Adalgisa S P Ferreira Lena M F Barros Rosamar E F Rezende Ana C S Santos Nastri Andrea G B Leite Leonora Z Piccoli Josiane Galvan Simone R S S Conde Manoel C P Soares Dimas A Kliemann Dennis A Bertolini Aline S O Kunyoshi André C Lyra Marcio K Oikawa Luciano V de Araújo Flair J Carrilho Maria C J Mendes-Corrêa João R Rebello Pinho

BACKGROUND Nucleoside/nucleotide analogue (NA) treatment causes selection pressure for HBV strains carrying mutations conferring NA resistance. Drug-resistance mutations occur in the reverse transcriptase (RT) region of the HBV polymerase gene and spontaneously arise during viral replication. These mutations can also alter the hepatitis B surface (HBs) protein and in some cases reduce binding t...

ژورنال: :hepatitis monthly 0
jeyanthi suppiah virology unit, institute for medical research, kuala lumpur, malaysia; virology unit, institute for medical research, jln pahang, 50588 kuala lumpur, malaysia. tel: +60-326162674 rozainanee mohd zain virology unit, institute for medical research, kuala lumpur, malaysia norazlah bahari pathology unit, selayang hospital, selangor, malaysia salbiah haji nawi microbiology unit, hospital kuala lumpur, kuala lumpur, malaysia zainah saat virology unit, institute for medical research, kuala lumpur, malaysia

conclusions our data suggested an intermediate prevalence of g1896a mutation among malaysian hepatitis b carriers. the stop codon mutation has a significant association with genotype b and patients with chronic hepatitis b and liver cirrhosis. patients and methods serum samples from 93 patients confirmed as hepatitis b carriers were collected for molecular assay. the whole genome of hbv was amp...

2013
Yifang Han Rui Pu Xue Han Jun Zhao Yuwei Zhang Qi Zhang Jianhua Yin Jiaxin Xie Qiuxia Shen Yang Deng Yibo Ding Weiping Li Juhong Li Hongwei Zhang Guangwen Cao

BACKGROUND Genetic polymorphisms of pri-miR-34b/c and pre-miR-196a2 have been reported to be associated with the susceptibility to cancers. However, the effect of these polymorphisms and their interactions with hepatitis B virus (HBV) mutations on the development of hepatocellular carcinoma (HCC) remains largely unknown. We hypothesized that these polymorphisms might interact with the HBV mutat...

2016
Qiushi Liu Masaharu Somiya Shun’ichi Kuroda

Currently, hepatitis B virus (HBV), upon attaching to human hepatocytes, is considered to interact first with heparan sulfate proteoglycan (HSPG) via an antigenic loop of HBV envelope S protein. Then, it is promptly transferred to the sodium taurocholate cotransporting polypeptide (NTCP) via the myristoylated N-terminal sequence of pre-S1 region (from Gly-2 to Gly-48, HBV genotype D), and it fi...

2011
Andrea Costantini Katia Marinelli Giulia Biagioni Alessia Monachetti Monica L Ferreri Luca Butini Maria Montroni Aldo Manzin Patrizia Bagnarelli

BACKGROUND Occult hepatitis B virus (HBV) infection (OBI) is characterized by HBV DNA persistence even though the pattern of serological markers indicates an otherwise resolved HBV infection. Although OBI is usually clinically silent, immunocompromised patients may experience reactivation of the liver disease. CASE PRESENTATION We report the case of an individual with human immunodeficiency v...

2014
Ileana Constantinescu Andrei-Antoniu Dinu Voicu Boscaiu Marius Niculescu

BACKGROUND Accurate and personalized molecular virological diagnosis of hepatitis B virus (HBV) infection is crucial for individualized selection of patients for antiviral therapy in Romania. OBJECTIVES We aimed to investigate HBV mutations in Romanian patients with chronic HBV infection, also to match HBV genotypes with HBV mutations identified and clinical outcomes. PATIENTS AND METHODS T...

2012
Linda Dunford Michael J. Carr Jonathan Dean Linh Thuy Nguyen Thu Hong Ta Thi Binh Thanh Nguyen Jeff Connell Suzie Coughlan Hien Tran Nguyen William W. Hall Lan Anh Nguyen Thi

Hepatitis B (HBV) infection is endemic in Viet Nam, with up to 8.4 million individuals estimated to be chronically infected. We describe results of a large, multicentre seroepidemiological and molecular study of the prevalence of HBV infection and blood-borne viral coinfections in Viet Nam. Individuals with varying risk factors for infection (n = 8654) were recruited from five centres; Ha Noi, ...

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