The 5-hydroxytryptamine 2C (5-HT(2C)) receptor subtype has received considerable attention as a target for drug discovery, having been implicated in a wide variety of disorders. Here, we describe the in vitro pharmacological profile of the novel 5-HT(2C) receptor-selective agonist vabicaserin [(-)-4,5,6,7,9,9a,10,11,12,12a-decahydrocyclopenta[c] [1,4]diazepino[6,7,1-ij]quinoline hydrochloride] ...

5-Hydroxytryptamine (5-HT) released from enterochromaffin cells regulates gastrointestinal function in either an excitatory or inhibitory manner. 5-HT(3) and 5-HT(4) receptors in the gut have been the focus of clinical studies on the management of gastrointestinal motility disorders. 5-HT stimulates intestinal propulsive reflexes through 5-HT(4) receptors. 5-HT(4) receptor agonists can stimulat...

Exogenous brassinolide (BR) application is a feasible measure to alleviate abiotic stresses on crop productivity. The effects of BR at the silking-stage accumulation, translocation, and remobilization dry matter (DM) nutrients (nitrogen, phosphorus, potassium) waxy maize exposed post-silking high temperature (HT) were studied using Jingkenuo2000 (JKN2000, heat-tolerant) Yunuo7 (YN7, heat-sensit...

The present study demonstrated that 5-HT receptor mRNA was expressed with moderate level in the NRM neurons. Most of 5-HT 1A 1A receptor mRNA positive cells were 5-HT neurons, suggesting the majority of 5-HT receptor in the NRM might be autoreceptors. Eight 1A hours after carrageenan inflammation, the expression of 5-HT receptor mRNA in the NRM neurons, especially in the 5-HT neurons, 1A was si...

Serotonin (5-HT) has provided a useful tool to study plasticity of nociceptive sensory neurons in Aplysia. Because noxious stimulation causes release of 5-HT and long-term hyperexcitability (LTH) of sensory neuron somata and because 5-HT treatment can induce long-term synaptic facilitation of sensory neuron synapses, a plausible hypothesis is that 5-HT also induces LTH of the sensory neuron som...

OBJECTIVE To investigate the involvement of serotonin (5-hydroxytryptamine - 5-HT) receptors in mediation of stress-induced arginine vasopressin (AVP) and oxytocin (OT) secretion in male rats. DESIGN Experiments on laboratory rats with control groups. METHODS Different stress paradigms were applied after pretreatment with intracerebroventricular infusion of saline or different 5-HT antagoni...

Understanding serotonergic (5-HT) signaling is critical for understanding human physiology, behavior, and neuropsychiatric disease. 5-HT mediates its actions via ionotropic and metabotropic 5-HT receptors. The 5-HT(1A) receptor is a metabotropic G protein-coupled receptor linked to the G(i/o) signaling pathway and has been specifically implicated in the pathogenesis of depression and anxiety. T...

Alterations of the serotonergic system in the prefrontal cortex (PFC) are implicated in psychiatric disorders such as schizophrenia and depression. Although abnormal synchronous activity is observed in the PFC of these patients, little is known about the role of serotonin (5-HT) in cortical synchrony. We found that 5-HT, released by electrical stimulation of the dorsal raphe nucleus (DRN) in an...

BACKGROUND 5-hydroxytryptamine (5-HT) is one of the major neurotransmitters widely distributed in the CNS. Several 5-HT receptor subtypes have been identified in the spinal dorsal horn which act on both pre- and postsynaptic sites of excitatory and inhibitory neurons. However, the receptor subtypes and sites of actions as well as underlying mechanism are not clarified rigorously. Several electr...

background: the influence of hashimoto’s thyroiditis (ht) with subclinical hypothyroidism or euthyroid status on the alteration of glucagon-like peptide (glp)-1 and glp-2 levels remains uncertain. materials and methods: twenty-four untreated ht patients with subclinical hypothyroidism, 24 euthyroid ht patients, and 24 age- and gender-matched controls were enrolled in the study. the levels of gl...