This work proposes a flow system suitable for the rapid screening of formaldehyde contaminated in food. The system is based on the concept of a flow analyzer with a Hantzsch reaction. An operating procedure was developed for multiple tasking and high sample throughput. This resulted in a significant sample throughput of 51 samples h(-1). Under the optimized conditions, linear calibration from 1...

An efficient and green method has been developed for the synthesis of new substituted Hantzsch thiazole derivatives in 79%-90% yield, via the one-pot multi-component procedure, by the reaction of 3-(bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one, thiourea and substituted benzaldehydes in the presence of silica supported tungstosilisic acid, as a reusable catalyst, under conventional heating or ...

In this study, multi component Hantzsch reaction was carried out between various  Aromatic Aldehyde with Dimedone,Ethyl acetateand ammonium acetate to produce polyhydroquinolinederivatives under solvent-free conditions at 110oC by a (Zinc oxide  nanocatalyst) as effective Lewis acid. The remarkable advantages offered by this method compared with other methods are a green catalyst, simple work-u...

Within the realm of catalytic asymmetric hydrogenation, the focus continues to be on the use of chiral metal complexes in conjunction with a hydrogen source. Recently, the widespread development of organocatalysis, including the invention of iminium activation, has led to the discovery of many new enantioselective transformations. Based on this strategy, a number of bioinspired processes for th...

Abstract A highly efficient and stable heterogeneous coordination polymer (CP) was successfully prepared by hydrothermal combination of silver 4,6-diamino-2-pyrimidinethiol. The characterized FT-IR, XRD, TGA, SEM, EDX, X-ray mapping Nitrogen adsorption–desorption analysis. Ag–CP exhibit excellent catalytic activity in multicomponent Hantzsch synthesis polyhydroquinolines under mild reaction con...

Herein, we describe the first total synthesis of trienylfuranol A, a fungal triene-substituted tetrahydrofuran metabolite. The stereoselectivity chiral center bearing trienyl side chain was diastereodivergently controlled by addition nucleophilic species on substituted ?-butyrolactone. Remarkably, C-nucleophilic or hydride onto oxocarbenium intermediate leads to opposite diastereoselectivity re...