Solutions exchange systems are responsible for the timing of drug application on patch clamp experiments. There are two basic strategies for generating a solution exchange. When slow exchanges are bearable, it is easier to perform the exchange inside the tubing system upstream of the exit port. On the other hand, fast, reproducible, exchanges are usually performed downstream of the exit port. A...

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The current studies endeavour to develop and validate a simple, sensitive robust reversed- phase (RP) high-performance liquid chromatography (HPLC) methodology for quantitative estimation of voriconazole (VRC), following systematic principles Analytical Quality-by-Design (AQbD). A comprehensive risk assessment plan, followed by factor screening employing Taguchi design, was executed select “vit...