Three-dimensional (3D) cell cultures offer greater physiological relevance than monolayer cultures for cellular interaction studies and compound screens. However, manual manipulations of these cultures can be laborious and challenges are amplified as sample throughput increases. We used the Biomek FXP Workstation to automate the culture and drug sensitivity screening of cancer spheroids in Perf...

Portable hanging scales are a common means of weighing young children. Weighing trousers used to suspend children from a hanging scale are uncomfortable and require insertion of the child's legs through the trousers. The 'weighing seat' holds the child in a more natural, comfortable, and secure position, thus increasing the child's acceptance of the weighing procedure, and making the procedure ...

Many mathematicians have a dismissive attitude towards paradoxes. This is unfortunate , because many paradoxes are rich in content, having connections with serious mathematical ideas as well as having pedagogical value in teaching elementary logical reasoning. An excellent example is the so-called " surprise examination paradox " (described below), which is an argument that seems at first to be...

Recent analysis of sequential algorithms resulted in their axiomatization and in a representation theorem stating that, for any sequential algorithm, there is an abstract state machine (ASM) with the same states, initial states and state transitions. That analysis, however, abstracted from details of intra-step computation, and the ASM, produced in the proof of the representation theorem, may a...

In Stage 1 of 4 experiments in which rats completed a water-maze blocking procedure, experimental groups were trained to use a predictive beacon (hanging above, connected to, or displaced from the platform) to find a submerged escape platform in the presence of predictive or irrelevant background cues and in the presence or absence of irrelevant landmarks. In Stage 2, a fixed beacon, landmarks,...

In preclinical trials, a sensitive functional test is required to detect changes in the motor behaviour of the SOD1G93A mouse model of amyotrophic lateral sclerosis (ALS). We evaluated changes in body weight and motor impairment in behavioural tests, such as the rotarod, the hanging-wire test and the treadmill, of transgenic and wild type mice. We found differences in detection of the onset of ...

We observed twenty cases of hanging over a period of six years of which 14 were males and six females. All were below fifty years of age. They used plastic ropes, jute ropes, dhotis, and sarees. Five of the females used sarees; suggesting that object used for ligature depends on accessibility to the object. All these cases happened in peridomestic areas like bath room, bed room, trees in the ba...