INTRODUCTION We incorporated patient feedback from human factors studies (HFS) in the patient-centric design and validation of ava®, an electromechanical device (e-Device) for self-injecting the anti-tumor necrosis factor certolizumab pegol (CZP). METHODS Healthcare professionals, caregivers, healthy volunteers, and patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylit...

We present a novel integrated device for preparing metaphase chromosomes spread slides (FISHprep). The quality of cytogenetic analysis from patient samples greatly relies on the efficiency of sample pre-treatment and/or slide preparation. In cytogenetic slide preparation, cell cultures are routinely used to process samples (for culture, arrest and fixation of cells) and/or to expand limited amo...

BACKGROUND Microfluidic-based systems are ideal for handling small microliter volumes of samples and reagents, but 'real-world' or clinical samples for bioanalysis are often on the milliliter scale. We aimed to develop and validate a large-volume centrifugal or compact disc-based device for blood plasma separation, capable of processing 2 ml undiluted blood samples. RESULTS This automated blo...

To support blind people in dealing with graphical user interfaces some two-dimensional Braille devices were developed. In order to ensure an efficient workflow not only the preparation of content, but also the handling of the device has to be well usable. In this paper, the redesign of a touch-sensitive pin-matrix device is discussed. At first, some mock-ups of additional input controls were de...

We deal with problems arising in the coupling of process and device simulators. It is analyzed what kind of data and algorithms such simulations are based on. An overview of existing technology computer-aided design data models is given. A generic object-oriented data model suitable for three-dimensional process and device simulations, the so-called WAFER-STATE-SERVER is presented. By taking ad...

Abstract. This paper presents a novel kinematics architecture with 4 DoFs (degrees of freedom) intended to be used as haptic interface for laparoscopic surgery. The proposed is result an association serial and parallel chains, each one handling part the whole device DoF. chain allows handle translation self-rotation handles two tilt motions, this in disjoint way natural gesture surgeon. hybrid-...

Congenital coronary artery fistula is an uncommon anomaly. Transcatheter coil embolization or Amplatzer vascular plug device closure of fistula is often done in symptomatic patients with safe accessibility to the feeding coronary artery. Embolization of Amplatzer vascular plug device is rare. We report an 11-year-old male child who presented to us with increasing shortness of breath for 7 years...