The Plasmodium falciparum (P. falciparum) (i.e. a protozoan parasite) has been the main cause of malaria which has led to the deaths of many children in sub-Saharan Africa[1,2]. Malaria leads to various abnormalities in children such as renal failure, anaemia and hepatic dysfunction[3,4]. Although several initiatives such as roll back malaria have been introduced by international organizations ...

BACKGROUND Determination of lipophilicity as a tool for predicting pharmacokinetic molecular behavior is limited by the predictive power of available experimental models of the biomembrane. There is current interest, therefore, in models that accurately simulate the biomembrane structure and function. A novel bio-device; a lipid thin film, was engineered as an alternative approach to the previo...

BMJ 1993;306:1247-52 To provide revised guidance on malaria prevention for the medical advisers oftravellers from the United Kingdom going overseas to malarious areas, a committee of those most involved in giving advice and with specialist expertise in the United Kingdom agreed a policy document. There is a need for all travellers to be aware of the risk of malaria and to take measures to avoid...

The COVID-19 pandemic triggered by SARS-CoV-2 is a worldwide health disaster. Main protease an attractive drug target among coronaviruses, due to its vital role in processing the polyproteins that are translated from viral RNA. There presently no exact or treatment for this disease caused SARS-CoV-2.Speeding up innovation immediately required. In present study, we report potential inhibitory ac...

Artemisinin and its derivatives are the most rapidly acting and efficacious antimalarial drugs currently available. Although resistance to these drugs has not been documented, there is growing concern about the potential for resistance to develop. In this paper we report the selection of parasite resistance to artelinic acid (AL) and artemisinin (QHS) in vitro and the molecular changes that occ...

Halofantrine (HF) is used in the treatment of uncomplicated multidrug-resistant Plasmodium falciparum malaria. Severe cardiotoxicity has been reported to be correlated with high plasma concentrations of HF but not with that of its metabolite N-debutylhalofantrine. The aim of this study was to investigate the effects of other antimalarial drugs and of ketoconazole, a typical cytochrome P-450 3A4...

Alternative drugs to chloroquine are required to prevent the deleterious effects of malaria in pregnancy. Fear of potential toxicity has limited antimalarial drug use in pregnancy. Animal toxicity studies have documented teratogenicity when antimalarials are administered at high dosages. Excepting the tetracyclines, there is no evidence to suggest that, at standard dosages, any of the antimalar...

OBJECTIVE To study the effects of malaria on pregnancy outcome. METHODS A case control study conducted on patients identified by ICD-9 coding system of the hospital medical records. Demographic and clinical data recorded on standardized data sheet and analyzed using SPSS 11.5 software. RESULTS Of the total patients, 67.4% were multigravid and 32.6% were primigravid with 78.6% of patients ha...