B7-H3, a member of the B7-family molecules, plays an important role in adaptive immune responses. In addition, B7-H3 is also expressed in several types of human cancers and is correlated with the poor outcome of cancer patients. However, its exact role in cancer is not known. In the present study, we compared B7-H3 expression in normal pancreas and pancreatic cancer tissue specimens, and determ...

B7 family proteins are important immune response regulators, and can mediate oncogenic signaling and cancer development. We have used human triple-negative breast cancer cell lines with different expression levels of B7-H3 to evaluate its effects on the sensitivity to 22 different anticancer compounds in a drug screen. API-2 (triciribidine) and everolimus (RAD-001), two inhibitors that target t...

Analysis of the data in Cambridge Structural Database (CSD) for compounds containing an {M(tpy)X3} motif (tpy = 2,2’:6’,2”-terpyridine, M any metal, X F, Cl, Br, I) reveals 17 isostructural mononuclear [M(tpy)X3] crystallizing without lattice solvent; both face-to-face π-stacking pyridine rings and C–H3/H3’…X hydrogen bonding appear to be equally important. Regardless coordination number (CN 6,...

AbstractObjective To explore differences between mothers' and fathers' complementary feeding practices. Methods An online survey of UK parents with a healthy child in age. Timing introducing solid foods adherence to guidelines were assessed. Dietary quality was measured using the Complementary Feeding Utility Index. Results In sample 60 mothers fathers (nondy...

B7-H3 is a new member of the B7 family. The receptor for B7-H3 has not been identified, but it seems to be expressed on activated T cells. Initial studies have shown that B7-H3 provides a stimulatory signal to T cells. However, recent studies suggest a negative regulatory role for B7-H3 in T cell responses. Thus, the immunological function of B7-H3 is controversial and unclear. In this study, w...

AbstractObjectives Quantify how observable characteristics contribute to influenza vaccination disparities among White, Black, and Hispanic nursing home (NH) residents. Design Retrospective cohort. Setting Participants Short- long-stay U.S. NH residents aged ≥65 years. Methods We linked Minimum Data Set (MDS) Medicare data LTCFocUS other facility dat...

ABSTRACT Background The seroprevalence of antibodies to SARS-CoV-2 in healthcare workers is variable throughout the world. This study compares use two antibody assays among large cohorts southern England. Methods cohort includes data obtained from staff at Western Sussex Hospitals NHS Foundation Trust (WSHT) and Brighton University (BSUH) during voluntary testing, usi...

AbstractBackground/purpose Coagulation complications are frequent, unwanted occurrences in extracorporeal membrane oxygenation (ECMO) treatment, possibly influenced by the pump ECMO-circuit. We hypothesized that fewer would occur with a smaller, heparin-coated ECMO system centrifugal (CP) than one roller (RP) and after conversion, complication rates decrease over time. Met...

Importance An estimated 13% of all US adults (18 years or older) have diabetes, and 34.5% meet criteria for prediabetes. The prevalences prediabetes diabetes are higher in older adults. Estimates the risk progression from to vary widely, perhaps because differences definition heterogeneity Diabetes is leading cause kidney failure new cases blindness among US. It also associated with in...