نتایج جستجو برای: gwas
تعداد نتایج: 6259 فیلتر نتایج به سال:
Over half of the familial predisposition to pre-eclampsia can be attributed to genetic factors in the mother and/or fetus. The search for genetic susceptibility variants has progressed through candidate gene studies, family-based linkage studies, and most recently genome-wide association studies (GWAS). It is unlikely that any single variant has a large effect on pre-eclampsia susceptibility; s...
The use of the three genetic models viz. additive, dominant and recessive in Genome-wide association study (GWAS) is a common powerful approach to between variants trait (disease). selection these depends on pattern inheritance scope study. GWAS typically focuses single-nucleotide polymorphism (SNPs) human diseases case-control setup. In order this type risk genotype phenotype for given pattern...
Significant advances in sequencing technologies and genome-wide association studies (GWAS) have revealed substantial insight into the genetic architecture of human phenotypes. In recent years, the application of this approach in bacteria has begun to reveal the genetic basis of bacterial host preference, antibiotic resistance, and virulence. Here, we consider relevant differences between bacter...
Genome-wide association studies (GWAS) have revolutionized the search for the variants underlying human complex diseases. However, in a typical GWAS, only a minority of the single-nucleotide polymorphisms (SNPs) with the strongest evidence of association is explained. One possible reason of complex diseases is the alterations in the activity of several biological pathways. Here we present a web...
Genome-wide association studies (GWAS) have been shown to be a powerful way of identifying novel susceptibility genes in systemic lupus erythematosus (SLE), as demonstrated by a series of publications in the past year. Lupus has been a late-comer to the GWAS community, being preceded by success stories for the GWAS approach in other autoimmune diseases, including type I diabetes, ankylosing spo...
We show that a normalized alignment free similarity measure, called D2z, can be used to detect potential regulatory relations for gene sets when little is known about the regulatory elements involved. One scenario where such gene sets arise is genome wide association studies (GWAS). In this work we consider a gene set from a GWAS on childhood general cognitive ability. We build a co-regulation ...
Leveraging population-distinct linkage equilibrium (LD) patterns, trans-ethnic follow-up of variants discovered from genome-wide association studies (GWAS) has proved to be useful in facilitating the identification of bona fide causal variants. We previously developed the preferential LD approach, a novel method that successfully identified causal variants driving the GWAS signals within Europe...
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