Multiple system atrophy (MSA) is a horrible and unrelenting neurodegenerative disorder with an uncertain etiology and pathophysiology. MSA is a unique proteinopathy in which alpha-synuclein (α-syn) accumulates preferentially in oligodendroglia rather than neurons. Glial cytoplasmic inclusions (GCIs) of α-syn are thought to elicit changes in oligodendrocyte function, such as reduced neurotrophic...

Using the Nambu–Jona-Lasinio (NJL) model we study chemical potential response of the pion and kaon masses as a function of temperature and chemical potential, i.e., ∂m ∂µ (T , µ). First, we obtain the responses assuming the vector–axial vector coupling is zero (gV =0). Then, we include a non-zero gV and study the effects of gV on the responses. We find that the behavior of ∂m ∂µ for the pion is...

Using the Nambu–Jona-Lasinio (NJL) model we study chemical potential response of the pion and kaon masses as a function of temperature and chemical potential, i.e., ∂m ∂µ (T , µ). First, we obtain the responses assuming the vector–axial vector coupling is zero (gV =0). Then, we include a non-zero gV and study the effects of gV on the responses. We find that the behavior of ∂m ∂µ for the pion is...

The observation of an electron electric-dipole moment EEDM would have major ramifications for the standard model of physics. Polar molecules offer a near-ideal laboratory for such searches due to the large effective electric field Feff , on order of tens of GV/cm that can be easily oriented in the laboratory frame. We present an improved method for simply and accurately determining Feff, in a h...

BACKGROUND Griseoviridin (GV) and viridogrisein (VG, also referred as etamycin), both biosynthesized by a distinct 105 kb biosynthetic gene cluster (BGC) in Streptomyces griseoviridis NRRL 2427, are a pair of synergistic streptogramin antibiotics and very important in treating infections of many multi-drug resistant microorganisms. Three transporter genes, sgvT1-T3 have been discovered within t...

Abstract. Atmospheric organic acids (OAs) are expected to enhance methanesulfonic acid (MSA)-driven new particle formation (NPF). However, the exact role of OAs in MSA-driven NPF remains unclear. Here, we employed a two-step strategy probe MSA–methylamine (MA) NPF. Initially, evaluated enhancing potential 12 commonly detected ternary MA–MSA–OA cluster by considering free energies (MSA)1(MA)1(OA...

OBJECTIVE Increased glycemic variability (GV) is associated with increased oxidative stress, vascular complications, and mortality in metabolic syndrome (MS) and diabetes mellitus patients. To investigate the relationship between GV and inflammatory parameters in obese children with insulin resistance (IR) and to elucidate their effects on the development of MS. METHODS Fifty obese adolescent...

BACKGROUND The role of glycemic variability (GV) in development of cardiovascular diseases remains controversial, and factors that determine glucose fluctuation in patients with diabetes are unknown. We investigated relationships between GV indices, kinds of oral hypoglycemic agents (OHAs), and cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM). METHODS We analyzed 2...

This paper analyzes the problem of the spectral enhancement technique using global variance (GV) in HMM-based speech synthesis. In the conventional GV-based parameter generation, spectral enhancement with variance compensation is achieved by considering a GV pdf with fixed parameters for every output utterances through the generation process. Although the spectral peaks of the generated traject...

Multiple system atrophy (MSA) is a sporadic, adult-onset disease characterized by progressive degeneration of nervous systems including cerebellar, pyramidal, extrapyramidal, and autonomic system. Although a few recent studies reported that cognitive impairments could occur in patients with MSA, prominent dementia with progressive decline is not a typical clinical manifestation of MSA. In parti...