Holt-Oram syndrome (HOS) is a developmental disorder inherited in an autosomal-dominant pattern. Affected organs are the heart and forelimbs with upper extremity skeletal defects and congenital heart malformation. In this study we present three cases of HOS in the same family. In one of these three individuals we detected a transition of C to T (CTG-GTT, V205V) in exon 7 of the TBX5 gene. This ...

In order to determine the prevalence of diabetes mellitus and its related factors in remote areas of Zanjan Province, this stud was performed in 1996. 1997 persons older than 30 years of age 706 (36%) male and 1271 (64%) female were selected by random sampling from all rural areas in Zanjan. FBS and 2h postprandial BS following 75 gm glucose were determined. In second stage, full 2h GTT was per...

Coffee and cocoa manufacturing produces large amounts of waste. Generated by-products contain bioactive compounds with antioxidant anti-inflammatory properties, suitable for treating metabolic syndrome (MetS). We aimed to compare the efficacy aqueous extracts flours from coffee pulp (CfPulp-E, CfPulp-F) shell (CcShell-E, CcShell-F) ameliorate MetS alterations induced by a high-fat diet (HFD). B...

Abstract Background and Aims Chronic kidney disease (CKD) is associated with high cardiovascular mortality rate, especially because of altered glucose metabolism insulin resistance. Fibroblast growth factor 19 (FGF19), an intestinal postprandial hormone, has been shown to improve metabolic disturbances In CKD, secretion FGF19 seems blunted in hemodialyzed patients but the role regulation this p...

conclusions self-care education can improve self-care behavior in women with gestational diabetes and it is also effective in impaired glucose tolerance. results after adjusting for the baseline score, the mean score of self-care behaviors was significantly higher in the intervention group than the control group four weeks after the intervention [adjusted mean difference: 19.5; 95% confidence in...

Background & Aims: Diabetes mellitus is one of the most common types of chronic disease leading to serious complications such as blindness, end stage renal disease (ESRD), neuropathy and cardiac disorders. Skin tag is a common benign skin tumor that its association with impaired carbohydrate metabolism has been reported in some studies. The aim of this study was to compare the frequency of diab...

Young barley leaf is consumed as a popular green-colored drink, which is named "Aojiru" in Japan. In the present study, we examined effects of young barley leaf powder (BL) on gastrointestinal transit time (GTT) and fecal moisture and weight in comparison with wheat bran (WB) in male Sprague-Dawley rats. In addition, an attempt was made to identify BL components responsible for these effects by...