DMF (dimethyl fumarate) exerts anti-inflammatory and pro-metabolic effects in a variety of cell types, and a formulation (BG-12) is being evaluated for monotherapy in multiple sclerosis patients. DMF modifies glutathione (GSH) levels that can induce expression of the anti-inflammatory protein HO-1 (haem oxygenase-1). In primary astrocytes and C6 glioma cells, BG-12 dose-dependently suppressed n...

The “Most Easy, Efficient and Low Cost Geothermal Systems for Retrofitting Civil Historical Buildings” (GEO4CIVHIC) project aims to accelerate the deployment of shallow geothermal systems heating cooling purposes when retrofitting existing historical buildings. Analyzing implementation process borehole heat exchangers (BHEs), allows understanding how promote long-term sustainability ener...

The “Most Easy, Efficient and Low Cost Geothermal Systems for Retrofitting Civil Historical Buildings” (GEO4CIVHIC) project aims to accelerate the deployment of shallow geothermal systems heating cooling purposes when retrofitting existing historical buildings. Analyzing implementation process borehole heat exchangers (BHEs), allows understanding how promote long-term sustainability ener...

In the process of development and utilization a large-scale borehole heat exchanger (BHE) array system, phenomenon load shifting within BHE can be observed. this paper, OpenGeoSys software coupled with TESPy toolkit is used to establish comprehensive numerical model system (without depicting pump part), behaviors between BHEs different design parameters are studied. The results show that outlet...

This research compares the potential environmental impacts of heat pumps with gas boilers and scenario analysis through utilising life cycle approach. The study analyses current situation baseline model assesses future applications Circular Economy (CE), Resource Efficiency (RE) Limited Growth (LG) scenarios. Then, hybrid low-carbon technologies different manufacturing scenarios are investigate...

In order to boost the use of shallow geothermal energy, reliable and sound information concerning its potential must be provided public energy decision-makers, among others. To this end, we developed a GIS-based methodology that allowed us estimate resource, economic environmental at regional scale. Our method focuses on closed-loop borehole heat exchanger systems, which are by far systems most...

According to the previous pieces of research, the building sector consumes about 40 % of total yield energy and produce one-third of GHG pollution emission. This point shows the significant potential in two aspects of energy optimization and pollution reduction in this field. The purpose of this research as a case study is to construct a residential building and develop the paths for reaching a...