PURPOSE To introduce a novel autorefractor design that is intended to be manufacturable at low cost and evaluate its performance in measuring refractive errors. METHODS We developed a handheld, open-view autorefractor (the "QuickSee" [QS]) that uses a simplified approach to wavefront sensing that forgoes moving parts and expensive components. Adult subjects (n = 41) were recruited to undergo ...

BACKGROUND Aldo-keto reductase family 1 member C3 (AKR1C3) is a key steroidogenic enzyme that is overexpressed in prostate cancer (PCa) and is associated with the development of castration-resistant prostate cancer (CRPC). The aim of this study was to investigate the correlation between the expression level of AKR1C3 and the progression of PCa. METHODS Sixty human prostate needle biopsy tissu...

Many plant-based products have been suggested as potential antidiabetic agents, but few have been shown to be effective in treating the symptoms of Type 2 diabetes mellitus (T2DM) in human studies, and little is known of their mechanisms of action. Extracts of Gymnema sylvestre (GS) have been used for the treatment of T2DM in India for centuries. The effects of a novel high molecular weight GS ...

OBJECTIVES Discordance between the Gleason score (GS) on needle biopsy (NB) and the GS of the radical prostatectomy (RP) specimen is a common finding. The objective of this study was to evaluate the prognostic significance of these discrepancies with respect to outcomes following RP. METHODS In the study, 6625 men treated by RP were categorized as having NB=RP (68.8%), NBRP ...

Citation: Becker EA, Forney KA, Thayre BJ, Debich AJ, Campbell GS, Whitaker K, Douglas AB, Gilles A, Hoopes R and Hildebrand JA (2017) Habitat-Based Density Models for Three Cetacean Species off Southern California Illustrate Pronounced Seasonal Differences. Front. Mar. Sci. 4:121. doi: 10.3389/fmars.2017.00121 Habitat-Based Density Models for Three Cetacean Species off Southern California Illu...

We evaluated the performance of four frequently used cholesterol test systems, using split-sample measurements with a panel of 79 patients' specimens and isotope dilution gas chromatography-mass spectrometry (ID GS-MS) as a comparison method. The test systems were from Beckman, a Boehringer Mannheim, Merck, and Johnson & Johnson Clinical Diagnostics, performed on the Synchron CX7, Hitachi 717, ...

where lm(I) denotes the ideal generated by the leading monomials of the elements of I. This condition has already been studied in Bayer et al. (1991) and it has been shown that (1.1) holds for any ideal and any term order if and only if π is flat. In this paper we study condition (1.1) under the additional assumption that R′ is not a general Noetherian commutative ring with identity but a field...

Introduction: Approximate entropy (ApEn) is a widely imposed metric to evaluate chaotic response and irregularities of RR-intervals from an electrocardiogram. Yet, the technique problematic due accurate choice tolerance (r) embedding dimension (M). We prescribed these responses in subjects exhibiting symptoms chronic obstructive pulmonary disease (COPD) we strived overcome this disadvantage by ...

GS 4071 is a potent carbocyclic transition-state analog inhibitor of influenza virus neuraminidase with activity against both influenza A and B viruses in vitro. GS 4116, the guanidino analog of GS 4071, is a 10-fold more potent inhibitor of influenza virus replication in tissue culture than GS 4071. In this study we determined the oral bioavailabilities of GS 4071, GS 4116, and their respectiv...