INTRODUCTION Recombinant human growth hormone (rhGH) is the first biosimilar drug approved by the European Medicines Agency in 2006, using the biosimilar registration process. It was authorised for the treatment of growth hormone deficiency, and growth disorders associated with Turner's syndrome, chronic renal failure, Prader-Willi syndrome, and growth disorders in children/adolescents born sma...

A study was conducted to document the physical environment and growth performance of nursery pigs in hoop structures compared with pigs reared in confinement nurseries. A series of six trials involving a total of 1,440 nursery pigs were conducted at two Iowa State University research farms from December 1999 to August 2000. Regardless of season, the confinement pigs grew faster and consumed mor...

Although new passive and active immunotherapy methods are emerging, unconjugated monoclonal antibodies remain the only kind of biological preparations approved for high-grade glioma therapy in clinical practice. In this review, we combine clinical and experimental data discussion. As antiangiogenic therapy is the standard of care for recurrent glioblastoma multiforme (GBM), we analyze major cli...

Background Clinical trials are known as the most valid medical research. It is able to promote medical evidences on prevention, diagnosis, screening, treatment, and quality of life because in this type of study, an intervention is intentionally performed on subjects. Therefore, it encompasses ethical concerns and considerations, especially when human subjects are studied. In other words, clinic...

With many broiler diets, particularly wheat–based diets, rate of passage of digesta limits intake and growth. In many trials, the relationship between feed intake and apparent metabolizable energy (AME) was negative or insignificant. In some trials, the limitation to voluntary intake was so severe that negative relationships existed between it and FCR. This is a consequence of the diversion of ...

the aim of this study was to evaluate blocked, random, gradual incremental and gradual decremental practice schedules on the acquisition and retention of different types of basketball pass (overhead, hand chest , single arm with dominate hand) in 8-10-year-old girls. for this purpose, 60 female students of second, third and fourth grade of elementary school were voluntarily selected and randoml...

according to the holy qur'an, human life is intermingled with trials, having a mutual relationship with man's perfection and elevation. as objective models of divine trials, prophets are chosen and reported intelligently in the qur'an. the central issue in this research is to draw a revealed pattern of the trial of prophets and analyze its components, emphasizing on the story of ...

Recent clinical trials have demonstrated the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) in the treatment of patients with advanced metastatic non-small cell lung cancer. Most of these recent trials were conducted in patients with EGFR mutation-positive tumors. As our knowledge of the EGFR mutation and its resistant pathways develops, the complexity of t...

As a potent antioxidant, Vitamin E may lessen the potentially harmful consequences of such oxidative stress to protect broilers against immune-pathological damage. Broiler chicken growth and viability are enhanced by supplementation. The present study aimed investigate effects dietary supplementation on broiler chickens’ performance health status. A total 48 one-day-old Ross chicks were randoml...