A simple food chain which consists of nutrient, prey and predator in which nutrient is growth limiting at low concentrations but growth inhibiting at high concentrations is investigated in this study. It is assumed that the nutrient concentration is separated into internal and external nutrient concentration and only the internal nutrient level is capable of catalyzing cell growth. It is shown ...

The nerve growth cone is bi-directionally attracted and repelled by the same cue molecules depending on the situations, while other non-neural chemotactic cells usually show uni-directional attraction or repulsion toward their specific cue molecules. However, how the growth cone differs from other non-neural cells remains unclear. Toward this question, we developed a theory for describing chemo...

A bacteriological investigation performed on the biopsies of 1 30 patients with gastrointestinal disorders at the GI section of Imam Khomeini hospital concluded in the isolation of 100 cases of Helicobacler pylori. The antibacterial effects of bismuth salts alone and in synergy with tetracycline and metronidazole were evaluated on the basis of disc diffusion method on 5 randomly selected pu...

T-cell immunoglobulin and mucin domain 3 (Tim-3) is an immune checkpoint target under investigation in immuno-oncology (IO) trials. Blockade of T-cell-Tim-3 enhances antitumor immunity. Here, we identify additional role for Tim-3 as a growth-suppressive receptor intrinsic to melanoma cells. Inhibition melanoma-Tim-3 by RNA interference promotes, while melanoma-specific overexpression attenuates...