Tinea capitis (TC) is a worldwide health problem and a specific therapeutic challenge. The objective of this study was to establish the causative agents and clinical types and to present management options for TC. From 1993 to 2002, we treated 354 children (61% were boys) with TC. The data for the period 1998-2002, were analyzed in detail. After clinical and Wood's light examination, specimens ...

Griseofulvin (GF) is an antifungal drug whose pharmaceutical activity can be improved by particle size reduction. In this study the rapid expansion of supercritical solution (RESS) was employed to micronize GF. Carbon dioxide (CO2) with cosolvent acetone was chosen as a supercritical mixed solvent. The solubility of GF in supercritical CO2 with cosolvent acetone was measured using a dynamic app...

In contrast to normal cells, malignant cells are frequently aneuploid and contain multiple centrosomes. To allow for bipolar mitotic division, supernumerary centrosomes are clustered into two functional spindle poles in many cancer cells. Recently, we have shown that griseofulvin forces tumor cells with supernumerary centrosomes to undergo multipolar mitoses resulting in apoptotic cell death. H...

BACKGROUND Serious skin disorders have been associated with the use of oral antifungals in a number of case reports and series of cases. However the incidence of these disorders remains unknown. METHODS We estimated the risk of serious skin disorders in a cohort of users of oral antifungals identified in the general population of the General Practice Research Database in the UK. The cohort in...

OBJECTIVES Arthroconidia have been considered as the primary cause of infection by dermatophytes. However, the in vitro antifungal testing evaluates the responses mainly of microconidia or hyphae, and dermatophytes in vivo often produce arthroconidia, a cellular structure presumably more resistant to antifungals. The aim of this study was to compare the in vitro susceptibility of microconidia a...

Combination therapy is one way of improving the cure rate of onychomycosis. The LION Study examined the efficacies of terbinafine and itraconazole. The Icelandic cohort of the study reported that after 5 years only 46% of the terbinafine-treated patients and 13% of the itraconazole-treated patients were still disease-free, suggesting that relapses and reinfections were common in the long term t...

A large part of new pharmaceutical substances are characterized by a poor solubility and high hydrophobicity, which might lead to a difference in drug adsorption between fasted and fed patients. We have previously evaluated the release of hydrophobic drugs from tablets based on Pemulen TR2 and showed that the release can be manipulated by adding surfactants. Here we further evaluate the possibi...