BACKGROUND Bacterial sepsis is associated with high morbidity and mortality in preterm infants. However, diagnosis of sepsis and identification of the causative agent remains challenging. Our aim was to determine genome-wide expression profiles of very low birth weight (VLBW) infants with and without bacterial sepsis and assess differences. METHODS This was a prospective observational double-...

Our study aimed to characterize the mechanisms underlying the attenuated cardiovascular responsiveness toward the renin-angiotensin system during sepsis. For this purpose, we determined the effects of experimental Gram-negative and Gram-positive sepsis in rats. We found that sepsis led to a ubiquitous upregulation of NO synthase isoform II expression and to pronounced hypotension. Despite incre...

To assess the pattern of antibiotic utilisation and outcome of patients with bacteraemia in the hospital. All positive blood cultures (BC) over a 12-month period from January 2011 to December 2011 were retrospectively reviewed. Positive BC were recorded in 54 patients. 51.9% of the patients received antibiotics before or soon after obtaining the BC, and ceftriaxone was the most frequently-presc...

OBJECTIVE To investigate how patients with bacteremic sepsis are managed in a tertiary care teaching hospital. PATIENTS AND METHODS Prospective observational study on patients with bacteremic sepsis. Clinical and microbiological characteristics of bacteremic sepsis were analyzed in relation to prognosis. Severity of the illness was quantitatively analyzed by the APACHE (Acute Physiology, Age,...

BackgroundThere is no one-size-fits-all empiric antimicrobial therapy for sepsis because the pathogens vary according to site of infection and have changed over time. Therefore, updating knowledge on spectrum necessary rapid administration appropriate antimicrobials.ObjectiveThe aim this study was elucidate current its variation by in sepsis.MethodsThis a prospective nationwide cohort consecuti...

Aim: To determine the bacterial spectrum and frequency of sepsis in infants children presenting to a tertiary care hospital, as well its association with sociodemographic factors. Methods: This retrospective cross-sectional research was performed at Department Pediatrics, Ziauddin University Hospital Karachi. A total 199 records age group from 29 days 12 years report positive blood culture were...

One hundred and fourty episodes of septicemic children seen at Songklanagarind Hospital during a period of two years were reviewed to determine factors related to mortality. One hundred episodes (70.4%) of septicemia were hospital-acquired in which 98 (69%) were caused by gram negative bacilli, with Pseudomonas being the most common agent. Thirty episodes were from gram-positive cocci and eight...

Cellulomonas denverensis is a small and thin gram-positive rod-shaped bacterium that was proposed as a new species in 2005. Here we report a female case of acute cholecystitis and sepsis in which C. denverensis was determined to be causative.