INTRODUCTION Multidrug-resistant (MDR) Gram-negative healthcare-associated infections are prevalent in Singaporean hospitals. An accurate assessment of the socioeconomic impact of these infections is necessary in order to facilitate appropriate resource allocation, and to judge the costeffectiveness of targeted interventions. MATERIALS AND METHODS A retrospective cohort study involving inpati...

INTRODUCTION The prevalence of extensively drug resistant gram negative bacilli (XDR-GNB) is rapidly progressing; however in Egypt data are sparse. We conducted the present study to quantify the incidence, risk factors and outcome of patients harboring XDR-GNB. METHODS A one year prospective study was done by collecting all the bacteriological reports for cultures sent from the surgical inten...

BACKGROUND Despite the frequent occurrence of bacteremia due to gram-negative organisms in patients with underlying permanent pacemakers (PPMs) or implantable cardioverter defibrillators (ICDs), the outcome and treatment of these patients has received scant attention. In patients with PPMs or ICDs who have Staphylococcus aureus bacteremia, 45% have PPM/ICD infection. METHODS We conducted a re...

The founding member of the inhibitor of apoptosis protein (IAP) family was originally identified as a cell death inhibitor. However, recent evidence suggests that IAPs are multifunctional signaling devices that influence diverse biological processes. To investigate the in vivo function of Drosophila melanogaster IAP2, we have generated diap2 null alleles. diap2 mutant animals develop normally a...

Bacterial infection in the first month after liver transplantation is a frequent complication that poses a serious risk for liver transplant recipients as contributes substantially to increased length of hospitalization and hospital costs being a leading cause of death in this period. Most of these infections are caused by gram-negative bacilli, although gram-positive infections, especially Ent...

INTRODUCTION Dacryocystitis is an infection and an inflammation of the lacrimal sac and is an important cause of ocular morbidity in India. OBJECTIVE To isolate and identify the bacterial patterns associated with dacryocystitis and to determine their antibacterial sensitivity pattern. MATERIALS AND METHODS A total of 100 lacrimal swab materials were subjected to bacterial analysis. Children...

Botryomycosis is a bacterial infection that presents with eosinophilic granules and colonies of either gram positive or gram negative organisms, although Staphylococcus aureus is most commonly identified. It has been confused with lung cancer or actinomycosis due to similar presentation and symptoms. Treatment of this infection consists of a combination of antibiotics and surgery. We present a ...

A declining pipeline of clinically useful antibiotics has made it imperative to develop more effective antimicrobial therapies, particularly against difficult-to-treat Gram-negative pathogens. Silver has been used as an antimicrobial since antiquity, yet its mechanism of action remains unclear. We show that silver disrupts multiple bacterial cellular processes, including disulfide bond formatio...

OBJECTIVE Infections due to Gram-negative bacteria exhibit seasonal trends, with peak infection rates during warmer months. We hypothesized that the likelihood of a bloodstream infection due to Gram-negative bacteria increases with proximity to the equator. We tested this hypothesis and identified geographical, climatic and social factors associated with this variability. DESIGN We establishe...

Yokenella regensburgei is a fermentative, motile, oxidase-negative, gram-negative bacillus belonging to the Enterobacteriaceae family and an opportunistic human pathogen that caused infections mainly in immunocompromised patients rarely immunocompetent individuals. Y. regensburgei, which generally found well water, insect guts, reptiles nature, can cause different types of such as septic arthri...