BACKGROUND Mitomycin C and etoposide have both demonstrated activity against gastric carcinoma. Etoposide is a topoisomerase II inhibitor with evidence for phase-specific and schedule-dependent activity. PATIENTS AND METHOD Twenty-eight consecutive patients with advanced upper gastrointestinal adenocarcinoma were treated with intravenous (i.v.) bolus mitomycin C 6 mg/m2 on day 1 every 21 days...

Introduction: Pedunculated ampullary adenoma is a rare periampullary tumor. There is still controversy regarding whether to perform local ampullectomy or radical resection for adenomas with severe dysplasia. Case Description: A 57-year-old man was diagnosed with a large, long pedunculated ampullary tumor arising from the second portion of the duodenum. Histologic examination of the biopsy speci...

To elucidate carcinogenesis in the endometrium, we investigated cyclin D1 immunoreactivities in 20 normal endometria, 20 endometrial hyperplasias and 141 endometrioid-type endometrial adenocarcinoma. We also evaluated the correlation of cyclin D1 expression with Ki-67, cyclin E, cyclin A, cdk2, p27 and p53, and clinicopathological parameters and prognosis. Cyclin D1 expression increased signifi...

Chronic inflammation has been considered an important risk factor for development of prostate cancer. Toll-like receptors (TLRs) recognize microbial moieties or endogenous molecules and play an important role in the triggering and promotion of inflammation. In this study, we examined whether expression of TLR4 and TLR5 was associated with progression of prostate transformation in the transgenic...

Background: Adenocarcinoma of the prostate is an invasive carcinoma, a neoplasm epithelial cells with secretory cell differentiation. Histomorphology glandular. The are sheets or single neoplasia, basal not seen in this carcinoma. Tumor-Infiltrating Lymphocytes (TILs) lymphocytes that migrate to tumor peritumoral cells. In malignancy, T lymphocyte infiltration can be found, indicating immune re...

Objective: The study aims to investigate the prognostic factors in uterine endometrioid adenocarcinoma that affect survival outcomes. 
 Materials and Methods: This retrospective includes 144 cases which underwent surgical treatment for adenocarcinoma. Demographic data tumour characteristics were evaluated lymph node metastasis. Stage I grade 1-2 tumours divided into lymphadenectomy non-lym...

The objective of this study is to evaluate the association between tumor grade and response to chemotherapy in patients with endometrioid endometrial adenocarcinoma. Patients with advanced or recurrent endometrioid endometrial adenocarcinoma of known tumor grade who received at least 3 cycles of chemotherapy were retrospectively identified at three institutions. RECIST 1.1 criteria were used to...

Submit Manuscript | http://medcraveonline.com Abbreviations: IM: Intestinal Metaplasia; EAC: Esophageal Adenocarcinoma; HGD: High Grade Dysplasia; LGD: Low Grade Dysplasia; GAVE: Gastric Astral Vascular Ectasia; GERD: Gastroesophageal Acid Reflux Disease; PPI: Proton Pump Inhibitor; HCC: Hepatocellular Carcinoma; ASGE: American Society of Gastrointestinal Endoscopy; BE: Barrett’s Esophagus; EGD...

Our objectives were to devise a cytologic grading system and determine whether it would predict survival of patients with solid-type pancreatic adenocarcinoma. We evaluated 116 consecutive patients from July 2000 to November 2002; they were followed up until September 2003. We scored the following features on rapid Romanowsky-stained endoscopic ultrasound-guided fine-needle aspiration smears: c...