INTRODUCTION The pathogenesis of perinatal hypoxic-ischemic brain damage is highly complex. OBJECTIVE The aim of this study was to assess the role of oxidative stress in hypoxic-ischemic brain injury and subsequent abnormal neurological outcome in infants with perinatal hypoxic-ischemic encephalopathy (HIE). We estimated perinatal oxidative brain damage measuring activity of glutathione perox...

Previous in vitro experiments have shown that hyperhomocysteinemia leads to oxidative inactivation of nitric oxide, in part by inhibiting the expression of cellular glutathione peroxidase (GPx-1). To elucidate the role of intracellular redox status on homocysteine-induced endothelial dysfunction and oxidant stress, heterozygous cystathionine -synthase–deficient (CBS ) and wild-type (CBS / ) mic...

BACKGROUND AND PURPOSE Plasma glutathione peroxidase (GPx-3) is a major antioxidant enzyme in plasma and the extracellular space that scavenges reactive oxygen species produced during normal metabolism or after oxidative insult. A deficiency of this enzyme increases extracellular oxidant stress, promotes platelet activation, and may promote oxidative posttranslational modification of fibrinogen...

Substantial evidence supports a key role for reactive oxygen species (ROS) in causing cumulative damage to cellular macromolecules, thereby contributing to senescence. Antioxidants can scavenge ROS while protein turnover removes and replaces oxidized proteins. How these defence systems vary with age and with metabolic demand is not well known. In the present study 2H5-phenylalanine was injected...

A role for allelic variation within the gene for the antioxidant selenoprotein glutathione peroxidase 1 (GPx-1) in the risk or etiology of breast cancer was investigated. By analyzing the frequency of a polymorphism within the GPx-1 gene resulting in a leucine or proline at codon 198, it was determined that the leucine-containing allele was more frequently associated with breast cancer than the...

Background The early imbalances of trace elements in type 1 diabetes (T1D) may cause disturbance of glucose metabolism and more oxidative stress that may enhance the development of insulin resistance and diabetic complications. We aim to evaluate the serum level of selenium (Se), zinc (Zn), magnesium (Mg), and copper (Cu), the degree of oxidative stress and evaluate their relations to glycemic ...

Summary The study aimed to investigate glutathione peroxidase (GPx) activity and (GSH) levels in the sperm of patients with unexplained infertility. samples were collected from subjects normal semen parameters divided into fertile infertile groups. Sperm analysis was performed according 2010 WHO criteria. Measurement GPx GSH by enzymatic assay kits. higher recorded spermatozoa seminal plasma gr...

BACKGROUND Oxidative stress has been linked to the progression of disease, including chronic kidney disease (CKD). The aim of the present study was to determine the association between single-nucleotide polymorphisms (SNPs) of the antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase and their activities and the progression of CKD. METHODS This is a prospe...