gold nanoparticles were synthesized by chemical reduction of haucl4 inside the pores of a polycarbonate-based membrane followed by dissolving the membrane in dichloromethane and further sonication. sonication time as the main affecting factor on the nanoparticle size was investigated. the characterization by transmission electron microscopy showed the formation of gold nanoparticles with diamet...

Understanding the patterns of noncovalent adsorption double-stranded nucleic acids (dsDNA) on gold nanoparticles (GNPs) was aim this study. It found that high-affinity motifs in DNA can and do act as an “anchor” for fixation whole molecule GNP (up to 98 ± 2 single-stranded (ss)DNA molecules per particle with diameter 13 nm). At same time, involvement intramolecular interaction negatively affect...

BACKGROUND Nanoparticle-metal oxide and gold represents a new class of important materials that are increasingly being developed for use in research and health related activities. The biological system being extremely critical requires the fundamental understanding on the influence of inorganic nanoparticles on cellular growth and functions. Our study was aimed to find out the effect of iron ox...

Gold nanoparticles (GNPs), have been demonstrated as effective preclinical radiosensitising agents in a range of cell models and radiation sources. These studies have also highlighted difficulty in predicted cellular radiobiological responses mediated by GNPs, based on physical assumptions alone, and therefore suggest a significant underlying biological component of response. This study aimed t...

Purpose: In radiation therapy, gold nanoparticles (GNPs) are regarded as a promising radiosensitizer candidate. Several studies have revealed a dose enhancement by GNPs in X-ray and even proton irradiation. However, these studies have been limited to the depth direction. The dose distribution in both depth and lateral directions is crucial to evaluate the full radio sensitizing effect. The purp...

Spatiotemporal control of protein structure and activity in biological systems has important and broad implications in biomedical sciences as evidenced by recent advances in optogenetic approaches. Here, this study demonstrates that nanosecond pulsed laser heating of gold nanoparticles (GNP) leads to an ultrahigh and ultrashort temperature increase, coined as "molecular hyperthermia", which cau...

Hybrid materials combining gold nanoparticles (GNP) of variable diameter and an organic thin layer of photochromic diarylethenes were achieved. Solid-state photoswitching based on ring-closure/ring-opening reaction was carried out under alternate UV and visible irradiations. In addition to the spectral changes due to the photochromism itself, the surface plasmon resonance related to the GNP is ...

Growing number of studies report on the improved sensitivity of various imaging modalities in detecting abnormalities within tumours. Surface enhanced Raman scattering (SERS) microscopy is a novel optical imaging technique which is advantageous in terms of greater multiplexing capability, minimal or no photobleaching of the Raman reporters, better spatial resolution and low signal-to-noise rati...

Purpose: Gold nanoparticles (GNPs) have attracted signi cant attention in the treatment of cancer due to their potential as novel radiation enhancers, particularly when functionalized with various targeting ligands. e aim of this study was to assess the biodistribution and pharmacokinetic characteristics of a novel choline-bound GNP (choline-GNP) stabilized with polyethelenimine (PEI). Methods:...