We report novel compound heterozygous mutations of the UDP-N-acetylglucosamine-2-epimerase and N-acetylmannosamine kinase (GNE) gene, c.302G>A (p.R101H) and c.617-4A>G, in a Japanese family with distal myopathy with rimmed vacuoles (DMRV) presenting with slow progression. The three patients could stand and walk even 36, 34, and 39 years after onset, respectively, although affected individuals b...

This paper deals with optimization methods solving the generalized Nash equilibrium problem (GNEP), which extends the standard Nash problem by allowing constraints. Two cases are considered: general GNEPs where constraint functions are individualized and jointly convex GNEPs where there is a common constraint function. Most recent methods are benchmarked against new methods. Numerical illustrat...

Many types of parameters have been proposed for the evaluation of vocal cord abnormalities by speech waveform analysis. However, none of them taken separately allows a reliable assessment of the presence and the degree of abnormality. In this study we proposed to combine three different parameters which take into account different consequences of the hoarseness. To assess the effectiveness of t...

voice parameters on a large voice database Dirk Michaelis and Hans Werner Strube Drittes Physikalisches Institut Georg-August-Universit at G ottingen B urgerstrasse 42-44 D-37073 G ottingen Phone +49-551 397731, 397729 Telefax +49-551 397720 ABSTRACT A new acoustic parameter for the description of hoarseness has been developed: The Glottal-to-Noise Excitation Factor (GNE-Factor). It shows t...

The Earth is a magnet. Its dipole character from e results massive currents within the molten portion of its core. These currents, presumably by gravitational in driven i energy, induce, the manner of a self-sustaining dynamo, a global dipolar magnetic field with t a magnitude of rouehly g 0.7 gauss at the gne ti poles. Although the ancient Chinese were familiar with the polar alignment of magn...