We have developed an autoradiographic method for estimating the oxidative and glycolytic components of local CMRglc (LCMRglc), using sequentially administered [18F]fluorodeoxyglucose (FDG) and [14C]-6-glucose (GLC). FDG-6-phosphate accumulation is proportional to the rate of glucose phosphorylation, which occurs before the divergence of glycolytic (GMg) and oxidative (GMo) glucose metabolism an...

BACKGROUND Solid organ transplant (SOT) recipients are a priority group for influenza vaccination and strategies enhancing immunogenicity are needed. METHODS We determined adverse reactions, changes in biomarkers of graft function and immune responses to two doses of the AS03-adjuvanted influenza A/09/H1N1 vaccine in 216 SOT recipients and in 138 controls after one dose. Antibody responses we...

A cohort of seronegative preclinical medical and dental students and another cohort of seronegative national service recruits who were immunized intramuscularly with a reduced dose (10 micrograms) of plasma-based hepatitis B vaccine (Merck, Sharp & Dohme) at the start of the study and at 1 month and 6 months thereafter were followed up for 5 years and 6 years, respectively. Among the medical an...

We present a proposal for an 8.4 metre off-axis optical/IR telescope to be located at Dome C, Antarctica. LAPCAT will use a mirror identical to the offset segment recently cast for the Giant Magellan Telescope (GMT) as a completely unobscured f/2.1 primary. With a cooled deformable Gregorian secondary in a dewar following prime focus, LAPCAT will allow for diffraction-limited imaging with only ...

BACKGROUND Many brain-injured patients referred for outpatient rehabilitation have executive deficits, notably difficulties with planning, problem-solving and goal directed behaviour. Goal Management Training (GMT) has proven to be an efficacious cognitive treatment for these problems. GMT entails learning and applying an algorithm, in which daily tasks are subdivided into multiple steps. Main ...

There are several efforts to map clinical guidelines to a form, which can be further processed by special programs. All these approaches have a common drawback: they do not allow to define a persistent connection between the original guideline and its computerized version. Therefore, it is often difficult to comprehend the translation process at a later time. This thesis introduces a tool that ...

While definitive winter measurements for Dome C must await until 2004, on the basis of existing data the Antarctic Dome sites promise the best conditions on the Earth for many astronomical observations. Because atmospheric turbulence is largely confined to a ~ 100 m ground layer, adaptive correction with a single deformable mirror conjugated to this layer should yield an 8-arcminute field of vi...

The protective anti-HBs titres were examined six-year post-immunisation with the Brazilian recombinant hepatitis B vaccine. After the primary vaccination, all adolescents (n = 89) responded with protective anti-HBs titres and had a geometric mean titre (GMT) of 4031.8 mIU/mL. In 2010, 94.5% maintained protective anti-HBs (> 10 mIU/mL) antibodies, with a GMT of 236.0 mIU/mL. A positive correlati...

The safety, tolerability and immunogenicity of inactivated hepatitis A vaccine (VAQTA, Merck and Co. Inc., West Point, PA, USA) were investigated in 28 seronegative healthy adult volunteers. The age range was 25-35 years, and the mean age was 29 years. Two doses of the vaccine, each containing 50 U of hepatitis A virus antigen, were administered into the deltoid region 24 weeks apart. No seriou...