Seven monoclonal antibodies (mAb) specific for defined discontinuous and continuous epitopes on glycoprotein D of herpes simplex virus type 1 (HSV-1) were surveyed for their capacity to protect against virus-induced corneal disease in a murine ocular infection model. A known amount of purified mAb was transferred passively to BALB/c mice 24 hr after topical infection with HSV-1 on their scarifi...

Human alpha interferon (IFN) significantly inhibits the replication of herpes simplex virus type 1 in human neuroblastoma cells. This inhibitory effect can be blocked by pretreatment with antiserum to IFN. We observed no significant differences in the expression of major nucleocapsid proteins, including VP5, between IFN-treated and untreated neuroblastoma cells. Electron micrographs demonstrate...

Glycosylation of proteins is the most complex form of posttranslational modification. Glycan chains of glycoproteins are involved in numerous biological recognition events, such as protein folding, cell–cell communication and adhesion, cell growth and differentiation, as well as bacterial and viral infection. As an alternative to glycoprotein synthesis, approaches to the construction of glycope...

morphogenesis and development of fungal organisms 3. Kirk, T. K. ( 1983) in ihe Fi/urnmiotc.$ Ftrn,qi (Smith, J . E.. Berry, I 10. 1 1 I . This could be one of the reasons for the Dresence of D. R. & Kristiansen. B.. eds.), vol. 4, pp. 265-295, Edward ;he' fl-ilucosidase during the first period of bioiynthesis. It has also been proposed that fl-glucosidase may be important for glycoprotein synt...

Cyclic depsipeptide antibiotic aureobasidin A (AbA) and its analogs were tested for the inhibitory activity of P-glycoprotein in multidrug resistant cancer cells as well as for the antifungal activity. Some analogs with lower antifungal activity than AbA showed higher inhibition of P-glycoproteins indicating difference of the structure-activity relationships between the two activities. Among Ab...

We report a novel peptide probe for the detection of neurokinin-1 receptor using disaggregation-caused signal enhancement. The probe was obtained via the aggregation of a modified substance P in a terpyridine-Fe (II) complex with Gd (III)-DOTA into well-defined nanostructures, which effectively weaken ligand fluorescence and slow the exchange rate of inner-sphere water molecules. This probe dis...

Human SP-D is a potent innate immune molecule whose presence at pulmonary mucosal surfaces allows its role in surveillance against pathogens. Higher levels of serum have been reported the patients with severe acute respiratory syndrome coronavirus (SARS-CoV). Studies suggested ability human to recognise spike glycoprotein SARS-CoV; interaction HCoV-229E strain leads viral inhibition bronchial e...

Beta 2 glycoprotein I (β2GPI) is a single chain 50 kDa highly glycosylated glycoprotein at an approximate concentration of 4 μM in cells. The abundance of this protein in plasma and its high state of preservation indicate the important role of this protein in mammalian. In addition, β2GPI has a particular structure in the fifth domain, and is categorized as the major antigen recognized by autoa...

-l, A lectin fraction has been isolated from mucus produced by the snail Helix aspersa by affinity chromatography of mucus protein on Sephadex G-100. The lectin is eluted with D-glucose. It agglutinates rabbit red blood cells but not human type A and is inhibited by o-GalNAc and to a lesser extent o-GlcNAc and D-Gal. 2. The anti-A agglutinin of the Helix albumin gland was isolated by the same m...

BACKGROUND Ulcerative colitis (UC) is a multi-factorial autoimmune disease. P-glycoprotein is encoded by the multidrug resistance 1 (MDR1) gene. The C3435T polymorphism in the MDR1 gene is correlated with low P-glycoprotein expression. Additionally, vitamin D has regulatory effects on the immune system. The aim of our study was to determine the association between the C3435T MDR1 polymorphism a...