Background. Most genetic disorders are caused by single nucleotide variations (SNVs) or small insertion/deletions (indels). High throughput sequencing has broadened the catalogue of human variation, including common polymorphisms, rare variations or disease causing mutations. However, identifying one variation among hundreds or thousands of others is still a complex task for biologists, genetic...

XNBC is intended to simulate biological neural networks. XNBC V9 is an important evolution of the previous versions of the XNBC package, a full featured application for computer naive neuroscientists. XNBC is controlled via a user-friendly interface based on XWindow, Motif (Lesstif) and GTK and produces native colour PostScript high quality graphic outputs. XNBC is a public domain software pack...

SUMMARY One of the more common uses of the program FingerPrint Contigs (FPC) is to assemble random restriction digest 'fingerprints' of overlapping genomic clones into contigs. To improve the rate of assembling contigs from large fingerprint databases we have adapted FPC so that it can be run in parallel on multiple processors and servers. The current version of 'parallelized FPC' has been used...

We report on ASCA energy spectra of Cir X-1 taken near its zero phase on 1994 August 4–5. The ASCA SIS detectors allow a much more detailed study of the iron K complex than has been possible before. We find that prior to a sudden upward flux transition the dominant iron K feature appears to consist of a large edge from neutral or nearly-neutral iron. The depth of the edge corresponds to an abso...

After more than a decade of actively accreting at about a tenth of the Eddington critical mass accretion rate, the neutron-star X-ray transient KS 1731–260 returned to quiescence in early 2001. We present a Chandra/ACIS-S observation taken several months after this transition. We detected the source at an unabsorbed flux of ∼ 2 × 10 erg cm s (0.5–10 keV). For a distance of 7 kpc, this results i...

As described in the review by Marek Abramowicz (these proceedings), accretion theory is at something of a crossroads. Many theoretical descriptions of observations have centered on the “hydrodynamic” approach of the “standard” Shakura & Sunyaev α-disk [1]; however, recent MHD simulations of (non-radiative) accretion flow have called into question the validity of this approach [2, 3]. There has ...

RTLinux-GPL is an RTOS which uses a dual-kernel approach, that is, executing a real-time kernel (RTLinux-GPL itself) jointly with a general purpose OS (Linux). By using this approach, complex real-time application with both, hard and soft real-time requirements can be implemented easier. However, the core of RTLinux-GPL is getting bloated and hard to maintain, with several out-of-date and not-w...

We present a dynamical model of the high mass X-ray binary LMC X-1 based on high-resolution optical spectroscopy and extensive optical and nearinfrared photometry. From our new optical data we find an orbital period of P = 3.90917±0.00005 days. We present a refined analysis of the All Sky Monitor data from RXTE and find an X-ray period of P = 3.9094±0.0008 days, which is consistent with the opt...

INTRODUCTION The aim of this study was to investigate the diagnostic performance of measuring antibodies to the glycopeptidolipid (GPL) core antigen specific to Mycobacterium avium complex (MAC) in patients with rheumatoid arthritis (RA). METHODS We cross-sectionally investigated anti-GPL antibodies and radiographs of 396 patients with RA. A diagnosis of MAC pulmonary disease (MAC-PD) was mad...