a number of evidences suggest that during ischemic stroke, serum iron and hemoglobin (hb) levels are changed. yet, there are few reports in the literature related to this issue and resolution of this mechanism requires further experiments. the aim of the present study was to investigate the potential role of serum iron and hemoglobin levels as a  biomarker in diagnosis of acute ischemic stroke....

Polymorphisms of the ITPA gene have been associated with anemia during combination therapy in hepatitis C virus (HCV)-monoinfected patients. Our aim was to confirm this association in HIV/HCV-coinfected patients. In this prospective, observational study, 73 HIV/HCV-coinfected patients treated with pegylated interferon plus ribavirin (RBV) were enrolled. Two single nucleotide polymorphisms withi...

conclusions hemodialysis exacerbates oxidative stress and conformational changes of hb in patients with diabetes on hemodialysis. the frap value can be used as a positive determinant, while pco and hb derivatives can be used as negative determinants of oxidative stress in patients with diabetes. background diabetes is associated with an increased generation of reactive oxygen species (ros), whi...

42 Background 43 Polymorphisms of the ITPA gene have been associated with anemia during 44 combination therapy in HCV mono-infected patients. Our aim was to confirm this 45 association in HIV/HCV co-infected patients 46 Methods 47 In this prospective, observational study, 73 HIV/HCV co-infected patients treated with 48 Peg-IFN plus RBV were enrolled. Two SNPs within or adjacent to ITPA gene (rs...

Acute normovolemic hemodilution (ANH) is a blood-conservation method in which whole blood (WB(ANH)) is sequestered into blood collection bags before the commencement of surgery. However, for cardiac surgery, extracorporeal circuit (ECC) priming techniques limit the amount of blood that may collected prior to the actual initiation of cardiopulmonary bypass (CPB). In this study, computational mod...

BACKGROUND Single-nucleotide polymorphisms (SNP) in the inosine triphosphate pyrophosphatase (ITPA) gene correlate with ribavirin (RBV)-induced anemia in patients with chronic hepatitis C (CHC) receiving combination therapy. Managing anemia is an early priority in the treatment process. OBJECTIVES The aim was to develop a predictive index based on ITPA SNP status to identify CHC patients at r...

PURPOSE Percutaneous nephrolithotomy (PCNL) is the procedure of choice for treating large renal stones. Pneumatic lithotripsy (Lithoclast®) is effective regardless of the stones' composition, and ultrasonic lithotripsy allows the aspiration of small debris during lithotripsy. We investigated the efficacy and safety of PCNL via Lithoclast® alone or combined with ultrasonic lithotripsy. MATERIA...

dine treatment before stavudine therapy was initiated. These patients had a mean MCV of 103.9 fL (range, 81.3–118.8 fL) at initiation of therapy and a statistically insignificant mean increase in MCV of 2.2 fL (range, 10.3–20.2 fL; P 5 .11) at least 3 months after stavudine was substituted. Stavudine was used in conjunction with lamivudine therapy for 79 (87%) of the patients. Of 12 patients ta...