نتایج جستجو برای: glucocerebrosidase
تعداد نتایج: 825 فیلتر نتایج به سال:
Journal:
:Blood Cells, Molecules, and Diseases
2013
Journal:
:Current Neurology and Neuroscience Reports
2013
Journal:
:The FEBS Journal
2018
Journal:
:Trends in Molecular Medicine
2011
Journal:
:Nature Chemical Biology
2010
2017
Fredj Ben Bdira
Wouter W Kallemeijn
Saskia V Oussoren
Saskia Scheij
Boris Bleijlevens
Bogdan I Florea
Cindy P A A van Roomen
Roelof Ottenhoff
Marielle J F M van Kooten
Marthe T C Walvoort
Martin D Witte
Rolf G Boot
Marcellus Ubbink
Herman S Overkleeft
Johannes M F G Aerts
Glucocerebrosidase (GBA) is a lysosomal β-glucosidase that degrades glucosylceramide. Its deficiency results in Gaucher disease (GD). We examined the effects of active site occupancy of GBA on its structural stability. For this, we made use of cyclophellitol-derived activity-based probes (ABPs) that bind irreversibly to the catalytic nucleophile (E340), and for comparison, we used the potent re...
Journal:
:Journal of Clinical Neuroscience
2016
Journal:
:Annals of Medicine
2013
Journal:
:Expert Opinion on Therapeutic Targets
2020
Journal:
:Human Molecular Genetics
1997
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