In this work, the dimensional synthesis of a spherical Parallel Manipulator (PM) with a 3PSU-IS kinematic chain is presented. The goal of the synthesis is to find a set of parameters that defines the PM with the best performance in terms of workspace capabilities, dexterity and isotropy. The PM is parametrized in terms of a reference element, and a non-directed search of these parameters is car...

BACKGROUND Duchenne muscular dystrophy (DMD) is caused by the absence of the cytoskeletal protein, dystrophin. In DMD patients, dilated cardiomyopathy leading to heart failure may occur during adolescence. However, early cardiac dysfunction is frequently undetected due to physical inactivity and generalized debilitation. The objective of this study is to determine the time course of cardiac fun...

BACKGROUND Rapid action stopping leads to global motor suppression. This is shown by studies using transcranial magnetic stimulation to measure corticospinal excitability of task-unrelated effectors (e.g., from the hand during speech stopping). We hypothesize that this global suppression relates to the STN of the basal ganglia. Several STN local field potential studies in PD patients have shown...

We present Nitro, a high-performance in-memory key-value storage engine used in Couchbase 4.5 Global Secondary Indexes. The Nitro storage engine is well suited for the recent hardware trends like large amounts of memory and many CPU cores. The storage engine leverages latch-free data structures and tries to achieve linear scalability for the index read-write operations. The Nitro storage engine...

We used real-time LDI to study regional variations in microcirculatory perfusion in healthy candidates to establish a new methodology for global perfusion body mapping that is based on intra-individual perfusion index ratios. Our study included 74 (37 female) healthy volunteers aged between 22 and 30 years (mean 24.49). Imaging was performed using a recent microcirculation-imaging camera (EasyL...

Abstract When a distributional model is chosen, the analytic relation between its shape parameters and values taken by some kurtosis indexes, especially if they are unconventional, rarely known. In addition, different indexes may provide contrasting evidence about level of global kurtosis, when varied. That happens because just few act “plainly” on namely so as to produce consistent modificatio...

The objective of this research was to examine the effects of inbreeding in the population of Holstein cattle in the Walloon region of Belgium. The effects of inbreeding on the global economic index and its components were studied by using data from the genetic evaluations of February 2004 for production, somatic cell score (SCS), computed from somatic cell counts and type. Inbreeding coefficien...

Background Staging vascular cognitive impairment (VCI) might be useful for sample selection in clinical trials and for guiding clinical decision-making. Clinical dementia rating (CDR) has been applied for staging cognitive impairments of different etiologies, but it may underestimate severity of non-Alzheimer's disease cognitive deficits. Methods Out of a total of 147 elderly subjects, 23 (me...

OBJECTIVE This work intends to evaluate the functional characteristics of the cerebral network during the successful memory encoding of TV commercials. METHODS We estimated the functional networks in the frequency domain from a set of high-resolution EEG data in a group of healthy subjects during the showing of commercial spots within a neutral documentary. We evaluated the differences in the...