نتایج جستجو برای: glioblastoma

تعداد نتایج: 25259  

Journal: :Molecular cancer therapeutics 2015
Yuri Chikano Takahiro Domoto Takuya Furuta Hemragul Sabit Ayako Kitano-Tamura Ilya V Pyko Takahisa Takino Yoshimichi Sai Yutaka Hayashi Hiroshi Sato Ken-ichi Miyamoto Mitsutoshi Nakada Toshinari Minamoto

The failure of current treatment options for glioblastoma stems from their inability to control tumor cell proliferation and invasion. Biologically targeted therapies offer great hope and one promising target is glycogen synthase kinase-3β (GSK3β), implicated in various diseases, including cancer. We previously reported that inhibition of GSK3β compromises the survival and proliferation of glio...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2011
Davide Sciuscio Annie-Claire Diserens Kristof van Dommelen Danielle Martinet Greg Jones Robert-Charles Janzer Claudio Pollo Marie-France Hamou Bernd Kaina Roger Stupp Marc Levivier Monika E Hegi

PURPOSE Quantitative methylation-specific tests suggest that not all cells in a glioblastoma with detectable promoter methylation of the O6-methylguanine DNA methyltransferase (MGMT) gene carry a methylated MGMT allele. This observation may indicate cell subpopulations with distinct MGMT status, raising the question of the clinically relevant cutoff of MGMT methylation therapy. Epigenetic silen...

2017
Felix Mircea Brehar Anca Violeta Gafencu Violeta Georgeta Trusca Elena Valeria Fuior Dorel Arsene Mirela Amaireh Andrei Giovani Mircea Radu Gorgan

Lissencephaly-1 (Lis1) protein is a dynein-binding protein involved in neural stem cell division, morphogenesis and motility. To determine whether Lis1 is a key factor in glioblastoma, we evaluated its expression and function in CD133+ glioblastoma cells. Global, Lis1 gene expression is similar in glioblastoma and normal samples. Interestingly, immunohistochemistry data indicate increased Lis1 ...

Journal: :Medical hypotheses 2012
Steven Lehrer

Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor, accounting for 52% of all primary brain tumor cases and 20% of all intracranial tumors. Recently, evidence for a viral cause has been postulated, possibly cytomegalovirus (CMV). In one report, 80% of patients with newly diagnosed glioblastoma multiforme had detectable cytomegalovirus DNA in their periphe...

2012
Ming-Fei Lang Su Yang Chunnian Zhao Guoqiang Sun Kiyohito Murai Xiwei Wu Jinhui Wang Hanlin Gao Christine E. Brown Xiaoxuan Liu Jiehua Zhou Ling Peng John J. Rossi Yanhong Shi

A major challenge in cancer research field is to define molecular features that distinguish cancer stem cells from normal stem cells. In this study, we compared microRNA (miRNA) expression profiles in human glioblastoma stem cells and normal neural stem cells using combined microarray and deep sequencing analyses. These studies allowed us to identify a set of 10 miRNAs that are considerably up-...

2013
Zhixiang Cheng Yuanying Gong Kaihua Lu Xiang Lu Larry A. Pierce Reid C. Thompson Susanne Muller Stefan Knapp Jialiang Wang

Purpose: Glioblastoma is refractory to conventional therapies. The bromodomain and extraterminal domain (BET) proteins are epigenetic readers that selectively bind to acetylated lysine residues on histone tails. These proteins recently emerged as important therapeutic targets in NUT midline carcinoma and several types of hematopoietic cancers. In this study, the therapeutic potential of a novel...

2014
Jie Li Shan Zhu David Kozono Kimberly Ng Diahnn Futalan Ying Shen Johnny C. Akers Tyler Steed Deepa Kushwaha Michael Schlabach Bob S. Carter Chang-Hyuk Kwon Frank Furnari Webster Cavenee Stephen Elledge Clark C. Chen

Glioblastoma remains one of the deadliest of human cancers, with most patients succumbing to the disease within two years of diagnosis. The available data suggest that simultaneous inactivation of critical nodes within the glioblastoma molecular circuitry will be required for meaningful clinical efficacy. We conducted parallel genome-wide shRNA screens to identify such nodes and uncovered a num...

Journal: :Cancer research 2005
Adriana Eramo Roberto Pallini Fiorenza Lotti Giovanni Sette Mariella Patti Monica Bartucci Lucia Ricci-Vitiani Michele Signore Giorgio Stassi Luigi M Larocca Lucio Crinò Cesare Peschle Ruggero De Maria

Life expectancy of patients affected by glioblastoma multiforme is extremely low. The therapeutic use of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been proposed to treat this disease based on its ability to kill glioma cell lines in vitro and in vivo. Here, we show that, differently from glioma cell lines, glioblastoma multiforme tumors were resistant to TRAIL stimulat...

Journal: :Molecular cancer therapeutics 2015
Han Shen Eric Hau Swapna Joshi Pierre J Dilda Kerrie L McDonald

Because radiotherapy significantly increases median survival in patients with glioblastoma, the modulation of radiation resistance is of significant interest. High glycolytic states of tumor cells are known to correlate strongly with radioresistance; thus, the concept of metabolic targeting needs to be investigated in combination with radiotherapy. Metabolically, the elevated glycolysis in glio...

2016
Chunming Jiang Fang Shen Jianmin Du Zhaoyang Hu Xiaoli Li Jin Su Xiaohua Wang Xianmei Huang

Increasing evidence has indicated that aberrant expression of miRNAs has been shown to be strongly implicated in the initiation and progression of glioblastoma. Here, we identified a novel tumor suppressive miRNA, miR-564, and investigated its role and therapeutic effect for glioblastoma. We showed that miR-564 was down-regulated in human glioblastoma tissues and cell lines. Introduction of miR...

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