CYP2C9 is a polymorphic enzyme that metabolizes a number of clinically important drugs. In this study, catalytic activities of seven alleles found in Japanese individuals, CYP2C9*3 (I359L), *13 (L90P), *26 (T130R), *28 (Q214L), *30 (A477T), *33 (R132Q), and *34 (R335Q), were assessed using three substrates (diclofenac, losartan, and glimepiride). When expressed in a baculovirus-insect cell syst...

Objective: Type 2 diabetes mellitus(T2DM) is a progressive disease, pharmacotherapy with a single agent does not generally provide durable glycaemic control over the long time. In this study two dipeptidyl peptidase-4 inhibitors vildagliptin and linagliptin was used for comparative study as add on therapy in type 2 diabetes mellitus patients inadequately controlled with dual combination metform...

The present study is to establish bi-layer tablets of Glimepiride and Captopril, of which Glimepiride as immediate release and Captopril as sustained release layers. Immediate release layer was prepared by direct compression method by using cross povidone as disintegrant and sustained release layer was prepared by direct compression method by using HPMC K4 as polymer. Both powder blends of imme...

9406–9411. 33. Karalliedde J, Buckingham R, Starkie M, Lorand D, Stewart M, Viberti G. Effect of various diuretic treatments on rosiglitazone-induced fluid retention. J Am Soc Nephrol 2006;17:3482–3490. 34. Mazzone T, Meyer PM, Feinstein SB, Davidson MH, Kondos GT, D’Agostino RB Sr, Perez A, Provost JC, Haffner SM. Effect of pioglitazone compared with glimepiride on carotid intima-media thickne...

Case A 64-year-old Japanese woman with diabetes mellitus was admitted for hypoglycemia. Her diabetes had been under good control with glimepiride, voglibose, exenatide, and metformin for a few years. Although overt proteinuria was observed, the serum creatinine values were within normal range during the routine outpatient follow-up. Hypoglycemic attack caused by glimepiride and loss of appetite...

This paper deals with the synthesis and characterization of a glimepiride-samarium complex a rare earth’s metal. Glimepiride is an oral hypoglycemic agent. The conductometric titrations were conducted using monovariation method which shows the ligand metal ratio as 2:1. Molar conductance value indicate that complex is non-ionic in nature. Analytical results agree to the molecular formula (C24H3...

BACKGROUND Addition of a sulphonylurea to metformin improves glycaemic control in type 2 diabetes, but is associated with hypoglycaemia and weight gain. We aimed to compare a dipeptidyl peptidase-4 inhibitor (linagliptin) against a commonly used sulphonylurea (glimepiride). METHODS In this 2-year, parallel-group, non-inferiority double-blind trial, outpatients with type 2 diabetes and glycate...

UNLABELLED (J Diabetes Invest, doi: 10.1111/j.2040-1124.2012.00223.x, 2012) Aims/Introduction:  We assessed the efficacy of liraglutide therapy in Japanese type 2 diabetic patients insufficiently controlled with basal-supported oral therapy (BOT). MATERIALS AND METHODS   We retrospectively analyzed the data of 37 patients who had postprandial hyperglycemia (≥10.0 mmol/L) with BOT (long-acting...

Objective: The aim of the study is to analyze the antidiabetic effect of oral administration of acetone extract of Carissa spinarum (C. spinarum) leaves on blood glucose, haemoglobin, plasma insulin and lipid peroxidation to alloxan-induced diabetic rats. Method: Diabetes mellitus was induced by injection of alloxan (150mg/kg body weight), via the intraparitoneally. The extract was administered...