Purpose. In order to improve the drug availability after intravitreal administration, solid lipid nanoparticles (SLNs) containing diclofenac were prepared. Methods. In this experimental study, 18 albino rabbits were included. In right and left eyes of all rabbits, SLNs containing diclofenac and commercial form of diclofenac (0.3 mg drug) were intravitreally injected, respectively. One, four, tw...

Normal human subjects were studied hourly by fluorophotometry to measure the normal circadian rhythm of aqueous humor flow. On a separate day, the subjects slept for approximately 1 hr after lunch; this short nap was not found to have any effect on aqueous flow. On a separate night, the subjects slept under a bright light of 2500 lux; the light was not found to have any effect on flow in the sl...

Nickel and cobalt (Ni-Co) binary oxide nanosheets with mesoporous structure are prepared by a facile approach based on the formation and disassociation of nickel/cobalt-citrate complex, and they show an ultra-high Faradaic capacitance up to 1846 F g(-1) and excellent rate capability. On this basic, advanced aqueous asymmetric supercapacitors (AASs) are successfully built by using the Ni-Co oxid...

Objective(s): A lot of researches have investigated the effects of topical cyclosporine A on the eye surface layers’ diseases. By now the main limitation in cyclosporine application is the low permeation of the drug into the posterior segments of the eye. The aim of present study was to formulate high permeable dosage form can be beneficial in the topical treatment of the uveitis. Materials and...

PURPOSE To evaluate the concentration and kinetics of dorzolamide in the aqueous humor after its topical application. METHODS Samples of aqueous humor were collected at the beginning of routine cataract surgery at defined intervals after topical application of a 2% solution of dorzolamide. After deep-frozen storage of the samples, drug extraction was achieved with a mixture of solvents. Quant...

BACKGROUND Various surgical methods are recommended for the therapy of chronic subdural hematoma (CSH). In this study, burr-hole continuous drainage (CD) and burr-hole one-time drainage (OTD) methods for the treatment of CSH are retrospectively compared. MATERIAL/METHODS Fifty patients with CSH referred to this clinic between July 1995 and December 2003 were selected for treatment. Twenty-one...

Primary angle closure glaucoma is one of the leading causes of blindness in Asia. Surgical intervention is often needed to control the intraocular pressure for patients with advanced glaucoma. The current surgical modalities include laser peripheral iridoplasty, lens extraction, trabeculectomy, goniosynechialysis, combined procedures, glaucoma implants, and cyclodestruction. The choice of surgi...

Present-day glaucoma implants, i.e., long-tube implants, were introduced by Molteno et al. in 1976 [31]. !e most commonly used implants include Molteno and Ahmed singleand doubleplate implants, and the Baerveldt and Krupin implants. All implants are long-tube implants based on the original Molteno design. !e Ahmed and Krupin implants are valved implants. !e most recent addition to tube-shunt de...