INTRODUCTION Mixed glandular-endocrine carcinomas are rare tumours of gastrointestinal tract (MANEC). They are more frequent in stomach and hardly one hundred cases have been described in colon. According to Lewis, they are classified into collision (side by side pattern), composite (intermingled) or amphicrine (neuroendocrine and glandular features inside a same cell). Collision tumours are re...

Equine gastric ulcer syndrome (EGUS) has been recognized as a clinical entity in horses for almost 3 decades. EGUS is common in all types of horses and clinical signs are variable and include inappetence/slowed eating, colic, weight loss, poor hair coat, poor performance and behavior changes. Anatomy of the stomach, low forage diets, intense/increased exercise, high concentrate diets, regular/p...

BACKGROUND The gastric lesions of various lymphomas were observed at the cellular level using endocytoscopy. METHODS Endocytoscopy and magnifying endoscopy with narrow band imaging (NBI) were performed in 17 patients with lymphomas of the stomach. The lesions consisted of 7 with low-grade mucosa-associated lymphoid tissue (MALT), 5 with gastric involvement by adult T-cell leukemia/lymphoma (A...

BACKGROUND Equine gastric glandular disease (EGGD) is a term used to classify erosive and ulcerative diseases of the glandular mucosa of the equine stomach. Epidemiologic studies of risk factors for EGGD have not been reported. OBJECTIVE To determine risk factors for EGGD. ANIMALS Cases (n = 83) had endoscopic evidence of EGGD; controls (n = 34) included healthy horses and horses with equin...

Sodium/hydrogen exchanger (NHE) 8 is an apically expressed membrane protein in the intestinal epithelial cells. It plays important roles in sodium absorption and bicarbonate secretion in the intestine. Although NHE8 mRNA has been detected in the stomach, the precise location and physiological role of NHE8 in the gastric glands remain unclear. In the current study, we successfully detected the e...

The goal of this study was to gather more clinical information about the relationship between Helicobacter species and gastric ulceration in horses. Twenty seven privately owned patients were selected for the clinical study. All horses were gastroscopically examined and biopsies were taken from the glandular mucosa. Stomach biopsies were examined using a PCR assay specific for Helicobacter pylo...

A novel mutual prodrug (MA-P) consisting of mefenamic acid (MA) and paracetamol (P) has been synthesized as a gastrosparing NSAID, devoid of ulcerogenic side effects. The structure of synthesized drug was confirmed by elemental analysis, infrared spectroscopy, 1H NMR spectroscopy and mass spectrometry.The kinetics of ester hydrolysis was studied by HPLC at pH 2, pH 7.4 as well as in human plasm...

Just as the term colic describes a clinical presentation and encompasses a large number of disorders, gastroduodenal ulceration describes a clinical finding, the cause of which is likely to be multifactorial and different from case to case. Within the umbrella term gastroduodenal ulceration are included symptomatic and asymptomatic cases, focal or multifocal ulceration involving the squamous or...

Helicobacter pylori (Hp) is a major causative factor for gastric disorders and epidemiological evidence has accumulated indicating a significant relationship with chronic active gastritis, peptic ulcer, atrophic gastritis, intestinal metaplasia, and lymphoma or cancer development (Marshall and Warren, 1984; Nomura et al., 1991; Uemura et al., 2001). In 1994, the World Health Organization/ Inter...

A new species of Pseudascarophis (Nematoda: Cystidicolidae) found in the stomach of Kyphosus sectatrix (Linnaeus) (Kyphosidae), off Rio de Janeiro, Brazil, is described. The new species can be differentiated from the other congeners by the presence of lateral alae, distinct but inconspicuous cephalic papillae at the anterior end, three pairs of precloacal and one pair of adcloacal papillae in m...