Mononuclear cell infiltrates are found in human renal ischemia-reperfusion injury (IRI), and peritubular T lymphocytes have been identified in experimental IRI. However, the role of T cells in the pathogenesis of renal IRI is unknown. We hypothesized that T cells are one of the important mediators of renal IRI. To test this hypothesis, we used an established mouse model of renal IRI, and evalua...

BACKGROUND The protective role of IL-11, an IL-6 family cytokine, has been implicated in ischemia/reperfusion injury (IRI) in the heart and kidney, but its role has not been elucidated in liver IRI. This study was designed to evaluate the effects of IL-11 and its mechanism of action on liver IRI in a mouse model. METHODS A partial (70%) warm liver IRI was induced by interrupting the artery/po...

We thank Wei and colleagues for their interest 1 in our report 2 on the susceptibility of diabetic models to renal ischemia-reperfusion injury (IRI) that involves hyperglycemia, p53 and mitochondrial pathway of apoptosis. We agree that reactive oxygen species (ROS) might be an important factor for heightened p53 activation by IRI in diabetic kidneys. ROS is produced in diabetic tissues and may ...

Ischemia-reperfusion injury (IRI) is induced as a result of reentry of the blood and oxygen to ischemic tissue. Antioxidant and some other drugs have protective effect on IRI. In many surgeries and clinical conditions IRI is counteract inevitable. Some anesthetic agents may have a protective role in this procedure. It is known that inhalational anesthetics possess protective effects against IRI...

The Global Initiative for Asthma (GINA) has emphasised the importance of assessing control in response to treatment in grading asthma severity [1]. However, many asthma patients are inadequately controlled despite conventional treatment. GINA also recognises a potential role for complementary medicine in asthma management [1]. Fenzian (Eumedic Ltd, Hungerford, UK) is a device that provides low ...

The distribution of salivary immunoreactive insulin (S-IRI) and its relation to plasma insulin (P-IRI) and other clinical and metabolic variables were investigated in 93 nondiabetic subjects (60 males, 33 females, ages 11-70 y). S-IRI was measured by RIA, with monoiodinated insulin as labeled antigen and with standards consisting of serial dilutions in saliva of known amounts of native insulin....

The first long-duration incoherent scatter (IS) radar observations over Millstone Hill (42.6 N, 288.5 E) and EISCAT Svalbard radar (ESR, 78.15 N, 16.05 E) from October 4 to November 4, 2002 are compared with the newly updated version of the IRI model (IRI2001). The present study showed that: (1) For the peak parameters hmF2 and foF2, the IRI results are in good agreement with the observations o...

Background: The impact of hepatic steatosis on bioenergetics following hepatic ischemia-reperfusion injury (IRI) remains controversial and is associated with variable reports on its outcome. Large numbers of studies have been published examining the relationship between hepatic steatosis and cellular bioenergetics following hepatic IRI. This systematic review evaluates these studies. Methods: A...