Abstract Background Osteoarthritis (OA) is one of the most prevalent joint diseases advanced age and a leading cause disability worldwide. Ageing major risk factor for articular cartilage (AC) degeneration that leads to OA, age-related decline in regenerative capacity accelerates OA progression. Here we demonstrate systemic transplantation unique population adult multipotent muscle-derived stem...

Ranged among laminopathies, Hutchinson-Gilford progeria syndrome is a syndrome that involves premature aging, leading usually to death at the age between 10 to 14 years predominatly due to a myocardial infarction or a stroke. In the lecture I shall overview the importance of molecular cell biology investigations that led to the discovery of the basic mechanism standing behind this rare syndrome...

A common feature of progeria syndromes is a premature aging phenotype and an enhanced accumulation of DNA damage arising from a compromised repair system. HGPS (Hutchinson-Gilford progeria syndrome) is a severe form of progeria in which patients accumulate progerin, a mutant lamin A protein derived from a splicing variant of the lamin A/C gene (LMNA). Progerin causes chromatin perturbations whi...