Peripheral Giant Cell Granuloma or so called “Giant cell epulis” is the most common oral giant cell lesion.It usually presents as a purplish-red soft tissue nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. This lesion probably does not represent a true neoplasm but it may be a reactive in nature which is believed to b...

The Langhans’ giant cell described in 1868 is a large cell with numerous nuclei arranged in a ring around the periphery of an eosinophilic cytoplasm.1’ 2 The cytoplasm is homogeneous or granular and may contain inclusions such as Mycobacterium tuberculosis. The foreign body type giant cell can be distinguished by the presence of nuclei throughout the substance of the cytoplasm rather than at th...

Bacterial growth without division was observed in a giant cell-producing strain of Escherichia coli K-12. Giant cell production is controlled by the lon(-) (failure of cell division after irradiation) and mon(-) (formation of irregularly shaped cells) genes. Irradiation of a lon(-)mon(-) strain (P678-A(4)) with low doses of ultraviolet or ionizing radiation results in the production of large, a...

This study was undertaken to determine whether mouse placental lactogen (mPL)-I, mPL-II, and proliferin (PLF) are expressed by the same population of placental giant cells at midpregnancy. Tissue sections from Day 9 of pregnancy were analyzed by double immunofluorescence staining. Sections were stained for PLF by use of a rhodamine-conjugated second antibody, and for mPL-I or mPL-II by use of a...

Multinucleated giant cells are an important feature of the granulomatous reaction in Crohn's disease (CD) but their cellular origin is poorly understood. The aim of this study was to discover if intestinal macrophages are capable of generating multinucleated giant cells in vitro in response to cytokine stimulation. Human intestinal macrophages were isolated from the intestinal mucosa of CD and ...

During their development and aging on solid substrates, yeast giant colonies produce ammonia, which acts as a quorum sensing molecule. Ammonia production is connected with alkalization of the surrounding medium and with extensive reprogramming of cell metabolism. In addition, ammonia signaling is important for both horizontal (colony centre versus colony margin) and vertical (upper versus lower...