نتایج جستجو برای: ghr
تعداد نتایج: 707 فیلتر نتایج به سال:
The growth hormone receptor (GHR) is potentially involved in prostate cancer through its role in stimulating insulin-like growth factor I production and its cellular effects on prostate epithelium. We have used a haplotype-based tagging approach within CAncer Prostate Sweden, a large retrospective case-control study of 2,863 cases and 1,737 controls to investigate if genetic variation in theGHR...
Associations between GHR and IGF-1 Gene Polymorphisms, and Reproductive Traits in Wenchang Chickens*
Alleles of physiological candidate genes for reproductive traits, insulin-like growth factor-1 (IGF-1), and growth hormone receptor (GHR) were assessed to determine their associations with total egg production (NE), average days of continual egg-laying (ADCE), and number of double yolk eggs (DYE) in Wenchang chickens (Chinese indigenous breed). PCR-RFLP was used for genotype identification. The...
Although both growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signaling were shown to regulate life span in lower organisms, the role of GH signaling in human longevity remains unclear. Because a GH receptor exon 3 deletion (d3-GHR) appears to modulate GH sensitivity in humans, we hypothesized that this polymorphism could play a role in human longevity. We report a linear increased...
ژن هورمون رشد ((GH ژنی نامزد (کاندیدا) برای رشد حیوانات اهلی است و هورمون رشد نقش مهمی در سوخت‌وساز (متابولیسم) رشد دارد. برای اینکه هورمون رشد بتواند در سوخت‌وساز رشد شرکت کند نیاز به گیرندههای آن (GHR) در سطح یاختههای هدف دارد. این پژوهش با هدف بررسی ارتباط چندریختی ژنهای GH و GHR با صفات لاشه در نژاد لری بختیاری انجام شد. برای این منظور، از سیاهرگ وداج تعداد 152 رأس گوسفند نژاد لری بختیار...
Forhead, A. J., J. Li, J. C. Saunders, M. J. Dauncey, R. S. Gilmour, and A. L. Fowden. Control of ovine hepatic growth hormone receptor and insulin-like growth factor I by thyroid hormones in utero. Am J Physiol Endocrinol Metab 278: E1166–E1174, 2000.—By use of RNase protection assays, hepatic growth hormone receptor (GHR) and insulinlike growth factor I (IGF-I) mRNA abundances were measured i...
GHR gene transcript heterogeneity may explain phenotypic variability in GHR pseudoexon (6Ψ) patients
The functional role of the exon 3 growth hormone receptor (d3GHR) polymorphism in human and its distributions in different populations is not clearly understood. The presence of full length growth hormone (flGHR) is the most important in metabolic risk factors. The aim of this study was to define the frequency distribution of d3GHR/full-length GHR in an Iranian population. The presence of the d...
We previously reported that EphA4, a member of the Eph family of receptor tyrosine kinases, is an important modulator of growth hormone (GH) signaling, leading to augmented synthesis of insulin-like growth factor 1 (IGF1) for postnatal body growth. In the present study, we report the molecular interactions of EphA4, GH receptor (GHR), Janus kinase 2 (JAK2), and signal transducer and activator o...
Previous studies have demonstrated that the p.Lys232Ala substitution in the acylCoA: diacylglycerol acyltransferase (DGAT1) gene and the p.Phe279Tyr mutation in the growth hormone receptor (GHR) gene are the causative quantitative trait loci underlying milk yield and composition on BTA14 and BTA20 respectively. To examine their applications in the genetic improvement of Chinese dairy cattle pro...
Although C2C12 myoblasts express low levels of growth hormone receptor (GHR), we failed to see any effect of exogenous growth hormone (GH) on cell proliferation or differentiation. C2C12 cells stably overexpressing (sixfold) more in GHR (C2C12(GHR)) grew faster than parental cells in media containing 2% serum, and proliferated while parental cells died, in the absence of serum. These effects we...
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