The aim of the present study was to examine the causal-effect of baseline (year 2004) serum γ-glutamyl transpeptidase (GGT) level with the prevalence of metabolic syndrome (MS) in year 2008. The study was comprised of male workers who underwent a regular health check-up in 2004 and 2008. MS was diagnosed according to the American Association of Clinical Endocrinologists (AACE) criteria. In the ...

BACKGROUND Serum gamma-glutamyltransferase (GGT) elevation likely contributes to cardiovascular (CV) mortality, however it has remained unknown whether a dose-response relationship exists between serum GGT and CV mortality. METHODS We searched the PubMed, EMBASE, and Cochrane library databases for prospective cohort studies published up to October 2, 2016. Summary hazard ratios (HRs) with the...

Objective. The aim of this study was to investigate the relationship between gamma-glutamyl transferase (GGT) levels, cerebrovascular risk factors, and distribution of cerebral infarct areas in patients with acute ischemic stroke (AIS). Patients and Methods. Sixty patients with AIS and 44 controls who had not cerebrovascular disease were included in the study. The patients were divided into fou...

The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Gamma-glutamyltransferase (GGT) is a well-established serum marker for alcohol-related liver disease. However, GGT's predictive utility applies well beyond liver disease: elevated GGT is linked to increased risk to a multitude of diseases and conditions, including cardiovascula...

OBJECTIVE To address the role of serum gamma-glutamyl transferase (GGT) as a marker of metastases in patients with renal cell carcinoma. METHODS Serum alkaline phosphatase and GGT were determined in 156 patients with localized renal cell carcinoma and 60 patients with metastases as proven by echosonography, computerized tomography and bone scan. The control group consisted of 50 healthy subje...

AIMS Gamma-glutamyl transferase (GGT) is a commonly used marker of ethanol abuse. However, although increasing age has also been suggested to elevate serum GGT activities, the magnitude of such effects on GGT in the assessment of ethanol intake have remained poorly defined. METHODS GGT activities from 208 heavy drinkers were compared with those from a reference population including 1330 moder...

BACKGROUND γ-Glutamyltransferase (GGT) has been linked to an increased risk of several cardiovascular outcomes; however, the relationship of GGT with sudden cardiac death (SCD) has not been investigated previously. We aimed to assess the association of GGT with risk of SCD. METHODS AND RESULTS Serum GGT activity was assessed at baseline in the Kuopio Ischemic Heart Disease prospective cohort ...

background elevated serum gamma-glutamyltransferase (ggt) is predictive of various cardiovascular (cv) risk factors including chronic kidney disease (ckd). elevated serum ggt has been recognized in smokers who are likely to develop ckd, but no study has focused on serum ggt and ckd in smokers. objectives the aim of this study was to clarify the associations between cigarette consumption, elevat...

OBJECTIVE To study the associations of baseline gamma-glutamyltransferase (GGT) and alanine transaminase (ALT) with incident diabetes among Asian Indian men with impaired glucose tolerance (IGT). METHODS In a 2 year prospective, randomised, controlled primary prevention study of diabetes, among 537 IGT men aged 35-55 years, 123 incident diabetes (DM) cases occurred. Anthropometric {body mass ...

Increased apoptosis of bone marrow granulocyte progenitor cells has been implicated in the pathophysiology of chronic idiopathic neutropenia (CIN) but the molecular abnormality underlying the cellular defect is unknown. In this report we study serum gamma-glutamyltranspeptidase (GGT) levels and GGT mRNA expression in peripheral blood cells of patients with CIN. We found that the low serum GGT i...