BACKGROUND Serum creatinine and cystatin C are used as markers of glomerular filtration rate (GFR). The performance of these GFR markers relative to exogenously measured GFR (mGFR) in HIV-positive individuals is not well established. METHODS We assessed the performance of the chronic kidney disease epidemiology collaboration equations based on serum concentrations of creatinine (eGFRcr), cyst...

The measurement of glomerular filtration rate (GFR) is the gold standard in kidney function assessment. Currently, investigators determine GFR by measuring the level of the endogenous biomarker creatinine or exogenously applied radioactive labeled inulin ((3)H or (14)C). Creatinine has the substantial drawback that proximal tubular secretion accounts for ~50% of total renal creatinine excretion...

Glomerular filtration rate (GFR) is the parameter that has been used most commonly as the “overall index” of renal function. Historically, inulin has been considered the ideal filtration marker used to determine GFR. The classic procedure for measuring inulin clearance is rigorous and includes a continuous intravenous infusion, multiple repeat blood and urine collections, and careful timing of ...

Cytokinin oxidase (CKX) plays a crucial role in plant growth and development by reversibly inactivating cytokinin (CTK). Twenty-four primer pairs, designed from ESTs of the TaCKX genes family of common wheat, were used to identify their allelic variations associated with grain size, weight, and filling rate in 169 recombinant inbred lines (RIL) derived from Jing 411 × Hongmangchun 21. TaCKX6a02...

Introduction . The relationship between kidney dysfunction and cardiovascular system is multifaceted. Thus, the value of such a potential marker glomerular filtration rate (GFR) as cystatin C cannot be underestimated predictor development complications atherogenesis factor in diabetes mellitus (DM) chronic disease (CKD). Objective was to evaluate role an patients with DM CKD. Materials methods ...

To the Editor: Inulin clearance (CIn) is the usual gold standard for evaluating glomerular filtration rate (GFR), but technical difficulties and patient inconvenience prevent its widespread use (1 ). The most commonly used marker for GFR is serum creatinine, but muscle wasting and tubular secretion may lead to overestimation of GFR (2, 3). Serum concentrations of the low-molecular weight protei...

Serum creatinine is commonly used as a marker of renal function, but increases in serum creatininemight not represent changes in glomerular filtration rate (GFR). INCB039110 (2-(3-(4-(7H-pyrrolo[2,3-day]pyrimidin4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl) piperidin-4-yl)azetidin-3-yl)acetonitrile) is an inhibitor of the Janus kinases (JAKs) with selectivity for JAK1....

Serum creatinine is commonly used as a marker of renal function, but increases in serum creatininemight not represent changes in glomerular filtration rate (GFR). INCB039110 (2-(3-(4-(7H-pyrrolo[2,3-day]pyrimidin4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl) piperidin-4-yl)azetidin-3-yl)acetonitrile) is an inhibitor of the Janus kinases (JAKs) with selectivity for JAK1....