OBJECTIVE The purpose of this study was to assess agreement between glomerular filtration rate (GFR) and the decline in GFR estimated with the Modification of Diet in Renal Disease (MDRD) Study Group equation or the Cockcroft-Gault formula and measured by the plasma clearance of 51Cr-EDTA. RESEARCH DESIGN AND METHODS We followed a cohort of 156 microalbuminuric type 2 diabetic patients for 8 ...

BACKGROUND We questioned which factors determine the risk for developing renal function impairment. To that purpose, we studied the incidence of newly diagnosed impaired renal function (GFR <60 mL/min/1.73m2) in the PREVEND cohort (N=8592), which is enriched for the presence of albuminuria, and which was first studied in 1997-1998. Of this cohort, 6894 subjects were studied again four years lat...

OBJECTIVE Albuminuria and impaired glomerular filtration rate (GFR) are each associated with poor health outcomes among individuals with diabetes. Joint associations of albuminuria and impaired GFR with mortality have not been comprehensively evaluated in this population. RESEARCH DESIGN AND METHODS This is a cohort study among Cardiovascular Health Study participants with diabetes, mean age ...

BACKGROUND Serum creatinine concentration (Scr) and creatinine based GFR estimating equations (eGFRcr) are commonly used as an estimate of GFR. However, serum creatinine concentration is also influenced by non-GFR determinants. This case report presents two elderly patients with normal Scr but elevated serum cystatin C concentration (Scys) where the exclusive assessment of Scr would have lead t...

We read with interest the article published by Bird et al about the reproducibility of measured GFR by iohexol and Cr-51-EDTA [ 1 ]. We would like to make one comment and to share our own results on this fundamental (although understudied) topic. As we already pointed out in a NDT editorial, we share the same reserves about the opportunity to index glomerular filtration rate (GFR) with body sur...

;25% false negatives. By contrast, plasma cystatin C better reflected GFR with the strongest correlation with Cr-labeled EDTA clearance and no false negatives. In a group of adult transplant recipients at steady-state renal function (average time since transplantation, 6 years), cystatin C was shown to have a better diagnostic value than serum creatinine for a GFR cutoff set at 60 mL/min (3 ). ...

Decreased glomerular filtration rate (GFR) and albuminuria are used in combination to define chronic kidney disease, but their separate and combined effects on cardiovascular and all-cause mortality have not been studied in the general population. The linked mortality file of the Third National Health and Nutrition Examination Survey includes data from 13 years of follow-up (1988-2000) for 14,5...

In clinical practice, the glomerular filtration rate (GFR) is often determined with serum creatinine. However, studies have shown cystatin C to be a better parameter for the diagnosis of impaired renal function. We compared GFR estimated by plasma cystatin C with GFR estimated by serum creatinine in a sample of 50 pediatric renal transplant recipients and 24 healthy children. The correlation be...

Glomerular filtration rate (GFR) is the gold standard in kidney function assessment and is used to determine progression of kidney disease and drug-induced kidney toxicity. One of the most accepted ways to assess GFR is by measuring the rate of disappearance of labeled inulin from the blood; as inulin is completely filtered at the kidneys’ glomeruli (but neither secreted nor reabsorbed by the t...

GFR markers Among newer GFR markers in ARF, serum cystatin C deserves evaluation since it has been shown more sensitive and accurate than serum creatinine in several settings, but has not been validated as a GFR indicator in ARF (1-2). Another endogenous marker, β2-microglobulin, has been suggested as a GFR estimate (3). Measuring tubular enzymuria could facilitate the early detection of renal ...