INTRODUCTION World Health Organization estimates that deaths resulting from diabetes will rise above 50% by the year 2020; hence urgent action is needed to reverse the trend notably through nutrition and lifestyle intervention among populations at risks. Studies have established that nutritional environment and physiology of the mother affects neonate's health at infancy and later in life thus ...

Abbreviations: HCG: Human Chorionic Gonadotropin; Β-hCG: Β-Human Chorionic Gonadotropin; DVT: Deep Vein Thrombosis; TMP-SMX: Trimethoprim and Sulfamethoxazole; EBV: Epstein Barr Virus; ALT: Alanine Aminotransferase; AST: Aspartate Aminotransferase; ALP: Alkaline Phosphatase, PT: Prothrombin Time; CBC: Complete Blood Cell; AFLP: Acute Fatty Liver of Pregnancy; DKA: Diabetic Ketoacidosis; GTD: Ge...

Background Studies highlight that continuous subcutaneous insulin infusion (CSII) during pregnancy leads to better glycemic control and lower glycated hemoglobin (HbA1c) without an increase in hypoglycemic episodes or diabetic ketoacidosis. Poor glycemic control can lead to birth defects, miscarriages, growth abnormalities and stillbirth. However, how to obtain better gestational outcomes is st...

Gestational diabetes mellitus (GDM) defined as impaired glucose tolerance affects approximately 6 % of all pregnant women who have never before had diabetes, but who do have high blood glucose levels during pregnancy. This study was done to evaluate the apoptosis in the neuronal cells in the CA1, CA2 and CA3 subfields of hippocampus and dentate gyrus in offspring of gestational diabetes at the ...

Materials and methods Diabetes was induced by streptozotocin (40 mg/Kg) in virgin female Wistar rats. After diabetes induction, rats were mated. The pregnant diabetic rats were put in four experimental groups, with n minimum=12 animals/ group: Non-diabetic; Non-diabetic Treated; Diabetic and Diabetic Treated. Hancornia speciosa leaf aqueous extract (600 mg/kg) was daily administered in all gest...

BACKGROUND Diabetes in pregnant women is associated with an increased risk of maternal and neonatal morbidity and remains a significant medical challenge. Diabetes during pregnancy may be divided into clinical diabetes and gestational diabetes. Experimental models are developed with the purpose of enhancing understanding of the pathophysiological mechanisms of diseases that affect humans. With ...

Most type 2 diabetic patients are obese who have increased number of visceral adipocytes. Those visceral adipocytes release several factors that enhance insulin resistance making diabetic treatment ineffective. It is known that significant percentages of visceral adipocytes are derived from mesenchymal stem cells and high glucose enhances adipogenic differentiation of mouse bone marrow-derived ...

T ype 1 diabetes complicates 1 of every 200 pregnancies and gestational diabetes a further 2–3% of pregnancies (1). Systemic atheromatous vascular disease can develop or accelerate during diabetic pregnancy. We and others (2) have observed similar vascular lesions in placental bed vessels (Fig. 1A) associated with impaired placental function and fetal growth. Genesis of atheroma involves adhere...