This study evaluated the risk of brain damage in neonates delivered at < 34 weeks following a prolonged latency after preterm premature rupture of membranes (pPROM). The medical records of 77 singletons delivered at < 34 weeks with pPROM and 66 singletons delivered at < 34 weeks with preterm labor and intact membranes were reviewed. Latency was divided into four intervals: < or = 24, > 24-< or ...

Over the past several decades, neuroscientists have become progressively aware of a group of cerebrovascular diseases in which the deep structures of the cerebrum are affected in preference to the cortex. Examples include subcortical dementia, subcortical infarction, intracerebral hemorrhage, and neonatal germinal matrix/intraventricular hemorrhage. To understand the pathogenesis of the disease...

Intraventricular hemorrhage with congenital cytomegalovirus (CMV) infection is rare and has been reported only in extremely premature infants or in association with thrombocytopenia. We report the first case of a full-term male infant with congenital CMV infection and intraventricular hemorrhage with a normal platelet count and coagulation profile. The infant also had a left subependymal cyst a...

BACKGROUND AND PURPOSE Germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) is the most common neurological problem of premature infants and has enormous financial and social impact. Despite this, there is no standardized animal model of IVH depicting acute brain injuries. METHODS We delivered rabbit-pups prematurely at 29-day gestation by C-section, administered intraperitoneal g...

We report the finding of multiple cerebral aneurysms in a pair of identical twins. One twin had subarachnoid hemorrhage and intracerebral hematoma; her sister had subarachnoid hemorrhage and intraventricular bleeding. Angiography in both cases showed multiple cerebral aneurysms. It is appropriate to recommend a cerebral angiographic examination of an asymptomatic twin after the other twin has s...

BACKGROUND AND PURPOSE Intraventricular hemorrhage is associated with high mortality and poor functional outcome. The use of intraventricular fibrinolytic (IVF) therapy as an intervention in intraventricular hemorrhage is an evolving therapy with conflicting reports in the literature. The goal of this study is to investigate the impact of IVF on mortality, functional outcome, ventriculitis, shu...

Obstructive hydrocephalus is a relatively common complication of intraventricular hemorrhage resulting in high morbidity and mortality. We report two cases of transient obstructive hydrocephalus caused by obstruction of mesencephalic duct in patients that presented with altered consciousness which resolved spontaneously in a few hours. In very rare cases, obstructive hydrocephalus due to intrav...