PURPOSE The epidermal growth factor receptor (EGFR) autocrine signaling pathway is involved in cancer development and progression. EGFR inhibitors such as C225 (cetuximab), a chimeric human-mouse anti-EGFR monoclonal antibody, and ZD1839 (gefitinib), a small molecule EGFR-selective tyrosine kinase inhibitor, are in advanced clinical development. The potential emergence of cancer cell resistance...

Die Anwendung Remote Task Control entstand in Zusammenarbeit der Firmen HORSCH und geo-konzept im Forschungsprojekt Geo Farm und ermöglicht eine durchgängig automatisierte Prozesskette von der Bereitstellung und Archivierung georeferenzierter Applikationskarten und Datenübertragung zur Landmaschine bis zur Ausführung und Dokumentation des variablen Applikationsprozesses im Feld. Das Projekt Geo...

We describe a basic Geo-coding service encompassing a geo-parsing tool and integrated digital gazetteer service. The development of a geo-parser comes from the need to explicitly georeference large resource collections such as the Statistical Accounts of Scotland which currently only contain implicit georeferences in the form of placennames thus making such collections inherently geographically...

We describe a basic Geo-coding service encompassing a geo-parsing tool and integrated digital gazetteer service. The development of a geo-parser comes from the need to explicitly georeference large resource collections such as the Statistical Accounts of Scotland which currently only contain implicit georeferences in the form of placennames thus making such collections inherently geographically...

Massive amount of data that are geo-tagged and associated with text information are being generated at an unprecedented scale. These geo-textual data cover a wide range of topics. Users are interested in receiving up-to-date geo-textual objects (e.g., geo-tagged Tweets) such that their locations meet users’ need and their texts are interesting to users. For example, a user may want to be update...

The objective of this study was to evaluate the cytotoxic activity of rosemary (REO, Rosmarinus officinalis L.), turmeric (CEO, Curcuma longa L.), and ginger (GEO, Zingiber officinale R.) essential oils in HeLa cells. Cytotoxicity tests were performed in vitro, using tetrazolium (MTT) and neutral red assays for evaluation of antiproliferative activity by different mechanisms, trypan blue assay ...

Space capabilities derived from the geosynchronous orbit (GEO) are unique and difficult to replicate in other orbital regions. Therefore, a premium is placed on the preservation of the GEO. An accurate understanding of the efficacy of debris mitigation measures is essential. Evidence seems to indicate retired systems in disposal orbits are shedding materials that transit the GEO region. In addi...