A field experiment was conducted during the Kharif season of2020 with four main plot treatments consisting of irrigation levels (No post sowing irrigation, one at flower initiation stage, pod filling stage and two irrigations each stage) five subplot as genotypes viz., MH 1142, 1468, 1703, 1762 1871 following split design by replicating thrice. Irrigating green gram, irrespective growth increas...

Objectives: To investigate the effect of enalapril, losartan, and surgical coronary revascularisation on endothelial function, and the role of the angiotensin converting enzyme (ACE) insertion (I)/deletion (D) polymorphism. Design: Randomised, controlled, blinded end point study. Setting: University tertiary referral cardiac centre. Patients and interventions: 49 men awaiting coronary artery by...

Adolescents are often sensitive to peer rejection, a factor that might contribute to the risk of affective disorder in this age group. Previous studies suggest a significant overlap among socioaffective brain regions involved in the response to social rejection, regions continuing to develop functionally during adolescence and regions influenced by monoamine oxidase A (MAOA) polymorphism. The c...

Platinum-based chemotherapy is the main type of I-line treatment of advanced and non-operative NSCLC patients without EGFR gene mutation. The excision repair cross-complementation group 1 (ERCC1) is an enzyme that executes the incision of the damaged DNA strand and removes platinum-induced DNA adducts. We investigated whether ERCC1 gene polymorphism has an effect on the response to chemotherapy...

The avianuncoupling protein (avUCP) is a member of the mitochondrial transporter superfamily that uncouples proton entry in the mitochondrial matrix from ATP synthesis. The polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method was used to estimate the allele and genotype frequencies of the UCP/HhaI polymorphisms and to determine associations between these polymorp...

Abstract Successful clinical drug development requires rational design of combination treatments based on preclinical data. Anti-hepatitis C virus (HCV) drugs exhibit significant diversity in antiviral effect. Dose-response assessments can be used to determine parameters profiling the diverse effect during treatment. In current study, a combined experimental and mathematical approaches were com...

Alterations of cyclin D1, one of the main regulators of the cell cycle, are known to be involved in various cancers. The CCDN1 G870A polymorphism causes production of a truncated variant with a shorter half-life and thus thought to impact the regulatory effect of CCDN1. The aim of the present study was to contribute to existing results to help to determine the prognostic value of this specific ...

We previously showed that provision of the folate recommended dietary allowance and either 300, 550, 1100, or 2200 mg/d choline for 12 wk resulted in diminished folate status and a tripling of plasma total homocysteine (tHcy) in men with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype. However, the substantial variation in tHcy within the 677TT genotype at wk 12 implied that seve...

main objective in wheat breeding programs is to improve high yielding and stable varieties possessing desirable morpho-physiological traits. this study was conducted to determine the stability of 18 winter and facultative bread wheat genotypes. the experiments carried out in 9 experimental stations (karadj- arak- ardebil- jolgerokh- miandoab- hamedan- mashad- qazvin- khoy) using a randomized co...