BACKGROUND Cutaneous squamous cell carcinoma (cSCC) is the second most common type of non-melanoma skin cancer (NMSC) globally. The aims of this study were to further systematically clarify the potential association of rs833061 (-460 C>T) and rs1570360 (-1154 G>A), two SNPs of VEGF, with the risk of cSCC and the prognostic impacts on cSCC patients. MATERIAL AND METHODS This hospital-based case-...

objective: neuregulin1 (nrg1) gene is among the most promising candidate genes for schizophrenia. this gene is located on 8p22-p12, a region with a reported linkage to schizophrenia. several studies have reported an association between schizophrenia and the 5′ end polymorphisms in this gene. however, some studies have failed to confirm the role of nrg1 gene in the pathogenesis of schizophrenia....

The present study aimed at investigating the relationship between rs1801320 (G>C), rs1801321 (G>T), and rs2619681 (C>T) RAD51 gene polymorphisms and the risk of breast cancer development in Saudi females. The genotypes were analyzed using TaqMan genotyping assay and polymerase chain reaction-restriction fragment length polymorphism. The genotype and allele frequencies were computed using chi-sq...

BACKGROUND Dysfunctions in the folate metabolism can result in DNA hypomethylation and abnormal chromosome segregation. Two common polymorphisms of this enzyme (C677T and A1298C) reduce its activity, but when associated with aneuploidy studies the results are conflicting. The objective of the present study is to analyze the MTHFR gene polymorphisms in women with Turner Syndrome and in a control...

The calpain-10 gene is expressed primarily in tissues important in glucose metabolism; thus, some of its polymorphisms have been associated with type 2 diabetes. In this study, we examined the association between the calpain-10 single-nucleotide polymorphism (SNP)-43, SNP-19, and SNP-63 and type 2 diabetes in Mexican mestizos. We included 211 patients and 152 non-diabetic subjects. Polymerase c...

Since the introduction of the short acting muscle relaxant succinyl dicholine (suxamethonium) in 1951 and the subsequent discovery that certain patients exhibited a greater than usual sensitivity to the drug, interest has been directed towards identifying the genetically controlled variants of serum cholinesterase (acylcholine acyl hydrolase E.C. 3.1.1.8). Some of these variants have been found...