ionizing radiation causes dna damage and chromosome abbreviations on normal cells. the radioprotective effect of celecoxib (clx) was investigated against genotoxicity induced by ionizing radiation in cultured human blood lymphocytes. peripheral blood samples were collected from human volunteers and were incubated at different concentrations at 1, 5, 10 and 50 μm of clx for two hours. at each do...

Hypothesis Anthocyanins possess well-known biological effects and suppress DNA damage induced by therapeutic topoisomerase poisons. Our study focusses on the modulatory effects of anthocyanidins-malvidin (MAL) and pelargonidin (PEL)-on topoisomerase II poison mitoxantrone (MXT)-induced cytotoxicity and genotoxicity in in vitro and in vivo conditions. Study design HepG2 cells were treated with M...

In today's changing conditions, there has been an increase in the consumption of ready-made food with change eating habits. Moreover, parallel to production, additives used. The dose amounts are determined as a result experimental analyses. However, some show long-term toxic effects on human body genotoxicity tests. this review, definition substances, purposes usage, classification, genotoxicit...

Fish have defense systems that are capable of repairing damages caused by xenobiotics like benzo[a]pyrene (BaP), so the aims this study were to identify BaP toxicity in melanomacrophages (MMs) cytoskeleton, evaluate melanin area MMs, and analyze genotoxicity. Rainbow trout juveniles (n = 24) split 48h 7d treatments received 2 mg/kg BaP. After experiment, blood samples collected liver was remove...

Genotoxicity in wastewater and reclaimed water now is gaining increased attention because of genotoxins' potential damage to the ecosystem and human health. The effect of ozonation on genotoxicity in reclaimed water was investigated. It was found that ozonation decreased the genotoxicy dramatically in three tertiary treatment plants. In the further batch ozonation experiment in laboratory, seco...

Formaldehyde, classified by the IARC as carcinogenic in humans and experimental animals, is a chemical agent that is widely used in histopathology laboratories. The exposure to this substance is epidemiologically linked to cancer and to nuclear changes detected by the cytokinesis-block micronucleus test (CBMN). This method is extensively used in molecular epidemiology, since it provides informa...

A bioanalytical test battery was used for monitoring organic micropollutants across an indirect potable reuse scheme testing sites across the complete water cycle from sewage to drinking water to assess the efficacy of different treatment barriers. The indirect potable reuse scheme consists of seven treatment barriers: (1) source control, (2) wastewater treatment plant, (3) microfiltration, (4)...

Rebaudioside A (Reb A) is a steviol glycoside isolated from the leaves of the Stevia rebaudiana plant. This non-nutritive, natural sweetener is reported to be 250-450 times sweeter than sucrose and has potential for wide use in the US diet, and is used in Japan and South America today. The safety of Reb A has been investigated in several recently published studies and information on genotoxicit...

Higher plants have been proposed as test organisms for the detection of genotoxic substances in the environment. Several plant test systems are already in use and are found to be as sensitive and reliable as other short-term tests. Allium cepa is one of these plants, which has been used in different studies to detect chromosome aberrations induced by chemicals. The use of non-animal test method...