Intranasal administration of live attenuated Bordetella pertussis, from which the pertussis toxin gene has been deleted, has previously been shown to give rise to high levels of serum immunoglobulin G (IgG) antibodies against both the protective antigen filamentous hemagglutinin (FHA) and heterologous antigens genetically fused to FHA. Here, we extend these results by demonstrating that anti-FH...

OBJECTIVE The objective of this study was to assess whether antibiotic therapy plus tocolysis given to women in preterm labor would prolong pregnancy compared with tocolysis alone. METHODS A randomized, double-blind trial of intravenous mezlocillin and oral erythromycin therapy vs. placebo was used in addition to tocolysis among women in preterm labor < or =34 weeks gestation with intact memb...

Mice with disrupted beta 2-microglobulin (beta 2m-/-), I-A (class II-/-), or CD4 (CD4-/-) genes were examined for their capacity to resolve Chlamydia trachomatis genital tract infection. C57BL/6 and beta 2m-/- mice resolved infection similarly and were culture negative by 4 to 5 weeks following infection. Conversely, major histocompatibility complex (MHC) class II-/- mice failed to resolve infe...

background: the accuracy of diagnostic assays in human papillomavirus (hpv) genital infection and cervical cancer has remained a clinical challenge in diagnosis.  evidence indicates that a large proportion of cervical cancer can be prevented through organized care for hpv and testing. countries with low per capita income, such as iran and its neighbours, have no national organized program for c...

Introduction Pelvic inflammatory disease (PID) is a polymicrobial infection of upper genital tract (usually fallopian tubes).It is a serious infectious disease of sexually active women with sequelae such as infertility and ectopic pregnancy (1, 2). It is most commonly caused by Neisseria gonorrhoea, Chlamydia trachomatis and other aerobic and anaerobic pathogens (3, 4). Most patients of PID are...

BACKGROUND Genital tract infections and obesity are both sources of oxidative stress. Alterations in immune and antioxidant parameters may arise from this or from an indeterminate autoimmune mechanism. OBJECTIVE This study aimed to investigate the association of Chlamydial infection, obesity and oxidative response with tubal infertility in Nigerian women. METHODS It was a case-control study...

Correspondence : Nahid Arianpour, Tehran, Iran. Tel: 912-2977306 Fax: 2188021913 E mail: [email protected] causes of maternal death for many decades (2). Infection made up 13% of pregnancy related deaths and was the fifth leading cause of death. In majority of instances bacteria responsible for postpartum infection are those that normally reside in the bowel (2). Most female pelvic infections...

The male factor contributes approximately 50% to infertility-related cases in couples with an estimated 12%-35% of these cases attributable to male genital tract infections. Depending on the nature of the infection, testicular sperm production, sperm transport, and sperm function can be compromised. Yet, infections are potentially treatable causes of infertility. Male genital tract infections a...

HPV is highly prevalent in reproductive age group and pregnancy of public health interest because itsunequivocal linkage to lower genital tract infections. Treatment infection lesions caused by theseinfections has be taken care after delivery also as these are involved disease progression carcinomas. Thesafety available therapies the risk vertical horizontal transmission JORRP neonatemust betak...

This guideline was produced by the European region of the International Union against sexually transmitted infections (IUSTI) and refers to ascending infections in the female genital tract unrelated to delivery and surgery and does not include actinomyces-related infection.