The incorporation of genomic sequencing techniques through next-generation has revolutionized clinical microbiology, innovating and improving the diagnosis infectious diseases. Today, whole genome in diseases many applications virology, bacteriology, antibiotic resistance, epidemiology, public health. With appearance SARS-CoV-2, importance analysis study genetic sequences been underlined. Since...

BACKGROUND The liver function test (LFT) is among the most commonly used clinical investigations to assess hepatic function, severity of liver diseases and the effect of therapies, as well as to detect drug-induced liver injury (DILI). AIMS To determine the relative contribution of genetic and environmental factors as well as test and quantify the effects of sex, age, BMI and alcohol consumpt...

Reecha Sofat specialist registrar in clinical pharmacology , Juan P Casas senior lecturer in epidemiology 2 , Anthony M Grosso honorary associate professor in clinical pharmacy 1 , Brian N C Prichard emeritus professor of clinical pharmacology , Liam Smeeth professor of clinical epidemiology , Raymond MacAllister professor of clinical pharmacology , Aroon D Hingorani professor of genetic epidem...

1Departments of Biomathematics and Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA 2Department of Biostatistics, School of Public Health, UCLA, Los Angeles, CA 90095, USA 3Division of Genetic and Molecular Epidemiology, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA 4The Computational Genomics Lab, Depart...

As you may imagine, I feel quite privileged to deliver the first presidential address to this Society. Although somewhat overlooked, in recent years the evolution of the field of genetic epidemiology has been just as dramatic as the evolution of other fields of genetic research, and the formation of this Society is a timely development. In 1954, W.J. Schull and I published a little textbook ent...

The introduction of genetic approaches in respiratory epidemiology is novel for most epidemiologists, and the post-genome phase poses new challenges. After describing specific questions pertinent to the field of asthma and chronic obstructive pulmonary disease, two main methodological aspects regarding technological and scientific advances are presented in this review. The first one concerns bi...